摘要
目的:分析夫妇血型不合的O型血孕妇所生新生儿发生ABO新生儿溶血病(ABO-HDN)的影响因素。方法:收集2020年3月至2021年3月出生并送检ABO溶血病患儿1415例临床资料。其中410例为O型血孕妇所生非O型新生儿,血清学3项实验诊断是否发生HDN。采用χ^(2)检验和二元logistic回归分析进行统计。结果:410例新生儿中诊断为ABO-HDN者230例(56.10%),其中女婴确诊率63.70%(135/212),明显高于男婴的48.00%(95/198)(P<0.05);确诊患儿中A型血占53.48%(123例),明显高于B型的46.52%(107例)(P<0.05);送检日龄1~3 d的新生儿确诊率90.43%(208/230),明显高于4~6 d的确诊率9.57%(22/230)(P<0.05);确诊新生儿中出生体重≥2500 g的婴儿占60.74%(212/349),明显高于出生体重<2500 g婴儿的29.51%(18/61)(P<0.01);二元logistic回归分析表明,婴儿性别、血型、送检日龄和出生体重是影响ABO-HDN的独立因素。结论:O型血孕妇所生非O型新生儿发生ABO-HDN受婴儿性别、血型、送检日龄和出生体重的影响,在诊治过程中应该关注这些因素,有助于进行预防和诊断。
Objective:To investigate the factors that affecting ABO hemolytic disease of the newborn(ABO-HDN)in neonates born to mothers with type O blood.Methods:A total of 1415 cases who were born in our hospital from March 2020 to March 2021 were collected and submitted for ABO hemolytic disease testing.Among them,410 cases of non-O newborns born to pregnant women with type O blood.All samples were subjected to three serological tests to confirm whether they suffered from hemolytic disease.Chi-square test and binary logistic regression analysis were used to take statistical analysis.Results:Among 410 cases,230(56.1%)were diagnosed as ABO-HDN,of which,the positive rate was higher in female infants(63.70%,135/212)than that in male infants(48.00%,95/198,P<0.05).The positive rate of blood group A(53.48%)was higher than that of group B(46.52%,P<0.05).The positive rate in testing time 1-3 days(90.43%)was higher than that in 4-6 days(9.57%,P<0.05).The positive rate of infants with birth weight was 2500 g or greater accounted for(60.74%,212/349),which was higher than that of the infants with birth weigh less than 2500 g(29.51%,18/61,P<0.01).Binary logistic regression analysis showed that gender,blood group,testing time and birth weight were independent factors influencing the diagnosis of ABO-HDN.Conclusion:The occurrence of ABO-HDN in non-O neonates born to pregnant women with blood type O may be affected by the baby’s gender,blood group,testing time and birth weight.These factors should be taken into consideration in the diagnosis and treatment process to help prevent and diagnosis.
作者
董青青
叶光勇
DONG Qingqing;YE Guangyong(Blood Transfusion Department of Clinical Laboratory,Womens Hospitals Zhejiang University-School of Medicine,Hangzhou,310006,China)
出处
《临床血液学杂志》
CAS
2022年第6期410-413,418,共5页
Journal of Clinical Hematology
基金
浙江省血液安全研究重点实验室开放研究基金项目(No:2018KF009)。
关键词
新生儿ABO溶血病
性别
血型
出生体重
ABO hemolytic disease of newborn
gender
blood type
birth weight
