摘要
目的分析急性脑梗死患者实施阿司匹林联合氯吡格雷治疗的效果。方法选取2019年5月至2020年5月牡丹江医学院附属红旗医院收治的100例急性脑梗死患者作为研究对象,采用抽签法将其分成参照组与试验组,每组各50例。参照组患者采用阿司匹林治疗,试验组在参照组的基础上采用氯吡格雷治疗。比较两组患者的治疗效果、治疗前后的神经功能评分及不良反应发生情况。结果试验组患者的治疗总有效率高于参照组,差异有统计学意义(P<0.05)。治疗前,两组患者的神经功能评分比较,差异无统计学意义(P>0.05);治疗1、5、10 d后,两组患者的神经功能评分低于治疗前,差异有统计学意义(P<0.05);治疗1、5、10 d后,试验组患者的神经功能评分低于参照组,差异有统计学意义(P<0.05)。试验组患者的不良反应总发生率低于参照组,差异有统计学意义(P<0.05)。结论急性脑梗死患者采用阿司匹林联合氯吡格雷治疗可提高治疗效果以及神经功能,降低不良反应发生率,值得在临床上推广和应用。
Objective To analyze the effect of Aspirin combined with Clopidogrel in the treatment of patients with acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction admitted to the Hongqi Hospital Affiliated to Mudanjiang Medical College from May 2019 to May 2020 were selected as the research objects,and they were divided into the reference group and the experimental group by drawing lots,with 50 cases in each group.The patients in the reference group received Aspirin.The experimental group was treated with Clopidogrel on the basis of the reference group.The therapeutic effect,the neurological function scores before and after treatment and the adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the reference group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in neurological function scores between the two groups(P>0.05).After 1,5 and 10 d of treatment,the neurological function scores of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After 1,5 and 10 d of treatment,the neurological function scores of the experimental group were lower than those of the reference group,and the differences were statistically significant(P<0.05).The total adverse reaction rate of the experimental group was lower than that of the reference group,and the difference was statistically significant(P<0.05).Conclusion The application of Aspirin combined with Clopidogrel in the treatment of acute cerebral infarction can improve the therapeutic effect and neurological function,and reduce the adverse reactions rate,which is worthy of clinical promotion and application.
作者
高雨秋
王慧然
张凯
GAO Yuqiu;WANG Huiran;ZHANG Kai(Department of Pharmacy,Hongqi Hospital Affilated to Mudanjiang Medical College,Heilongjiang Province,Mudanjiang157000,China)
出处
《中国当代医药》
CAS
2022年第19期129-131,135,共4页
China Modern Medicine
关键词
阿司匹林
氯吡格雷
急性脑梗死
治疗效果
Aspirin
Clopidogrel
Acute cerebral infarction
Treatment effect
