摘要
目的研究在不同孕周使用头孢曲松序贯苄星青霉素治疗对妊娠期梅毒患者围产结局和性生活质量的影响。方法选取2019年10月至2020年10月衡水市第三人民医院收治的78例妊娠期梅毒患者作为研究对象,根据不同的治疗时机分为观察组(n=39,治疗时机为≤20孕周)和对照组(n=39,治疗时机为>20孕周),两组均使用头孢曲松序贯苄星青霉素治疗。比较两组治疗效果、不良妊娠结局发生率及新生儿情况;所有患者均于产后进行6个月随访,观察患者恢复情况,并采用女性性功能指数(FSFI)量表评估和比较两组患者性生活质量。结果观察组治疗总有效率为92.31%,显著高于对照组的74.36%(P<0.05);观察组不良妊娠结局发生率为10.26%,明显低于对照组的46.15%(P<0.05);观察组新生儿体重、阿氏(Apgar)评分均显著高于对照组(P<0.05);观察组患者性交痛、阴道润滑度、性满意度及FSFI总分均显著高于对照组(P<0.05)。结论妊娠期梅毒患者于≤20孕周时行头孢曲松序贯苄星青霉素治疗可明显改善妊娠结局,治疗效果优于孕晚期治疗,且更有利于患者产后性生活质量的恢复。
Objective To study the effect of ceftriaxone sequential benzathine penicillin on perinatal outcome and quality of sexual life in pregnant syphilis patients at different gestational weeks.Methods 78 cases of pregnant syphiis patients admitted to Hengshui Third People's Hospital from October 2019 to October 2020 were selected as the research objects.According to the treatment time,the patients were divided into two groups.The observation group(n=39)was treated when the gestational age was≤20 weeks,and the control group(n=39)was treated when the gestational age was>20 weeks.Both groups were treated with ceftriaxone and benzathine penicillin.The curative effect and incidence of adverse pregnancy outcomes were analyzed,and the neonatal situation of the two groups was compared.All patients were followed up for 6 months after delivery to observe the recovery of patients,and the quality of sexual life of the two groups was evaluated by female sexual function index(FSFI)scale.Results The effective rate of the observation group was 92.31%,which was significantly higher than 74.36% of the control group(P<0.05).10.26% of the patients in the observation group had adverse pregnancy outcomes,which was significantly lower than 46.15% in the control group(P<0.05).The neonatal weight and Apgar score of the observation group were significantly higher than those of the control group(P<0.05).The sexual pain,vaginal lubrication,sexual satisfaction and FSFI total score of the observation group were significantly higher than those of the control group(P<0.05).Conclusions Cefriaxone combined with benzathine penicillin can significantly improve the pregnancy outcome of syphilis patients with gestational age≤20 weeks,which is conducive to the recovery of postpartum quality of sexual life.The treatment effect is better than the late treatment.
作者
陈风娥
史丽华
于江华
CHEN Feng'e;SHI Lihua;YU Jianghua(Department of Obstetrics and Gynecology,Hengshui Third People's Hospital,Hengshui 053000,Hebei,China)
出处
《中国性科学》
2022年第7期120-124,共5页
Chinese Journal of Human Sexuality
关键词
妊娠期梅毒
头孢曲松
苄星青霉素
孕周
妊娠结局
性生活质量
Pregnant syphilis
Ceftriaxone
Benzathine penicillin
Gestational age
Pregnancy outcome
Quality of sexual life
