摘要
目的 探究围术期预防性应用抗生素对外科手术患者切口感染的影响。方法 选择2017年2月至2020年10月收治的100例外科手术患者为研究对象,根据是否预防性应用抗生素将其分为对照组和试验组,每组50例。对照组术后实施抗生素干预,试验组围术期预防性应用抗生素。比较两组的感染发生情况、切口愈合情况、手术时间、住院时间、炎症因子水平、治疗满意度。结果 试验组的切口感染率及总感染率均低于对照组,差异具有统计学意义(P<0.05)。试验组的切口甲级愈合率为98.00%,高于对照组的86.00%,差异具有统计学意义(P<0.05)。两组的手术时间比较,差异无统计学意义(P>0.05);试验组的住院时间短于对照组,差异具有统计学意义(P<0.05)。术前,两组的C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);术后,两组的CRP、IL-6、IL-8、TNF-α水平均高于术前,但试验组低于对照组(P<0.05)。试验组的治疗满意度为96.00%,显著高于对照组的82.00%,差异具有统计学意义(P<0.05)。结论 外科手术患者围术期预防性应用抗生素能够显著降低感染率和炎症因子水平,促进切口愈合,缩短康复时间,提升治疗满意度,且对预后的改善有积极的意义,值得临床应用和推广。
Objective To explore the effect of perioperative prophylactic application of antibiotics on incision infection in surgical patients.Methods One hundred surgical patients admitted from February 2017 to October 2020 were selected as the research objects and divided into control group and experimental group according to whether antibiotics were used prophylactically,with 50 cases in each group.The control group was given antibiotics intervention after operation,and the experimental group was given perioperative prophylactic application of antibiotics.The occurrence of infection,wound healing,operation time,hospital stay,inflammatory factors levels and treatment satisfaction were compared between the two groups.Results The wound infection rate and total infection rate in the experimental group were lower than those in the control group,and the differences were statistically significant(P 0.05);the hospital stay in the experimental group was shorter than that in the control group,and the difference was statistically significant(P 0.05);after operation,the levels of CRP,IL-6,IL-8 and TNF-α in the two groups were higher than those before operation,but those in the experimental group were lower than the control group(P<0.05).The treatment satisfaction in the experimental group was 96.00%,which was significantly higher than 82.00% in the control group,and the difference was statistically significant(P<0.05).Conclusion Perioperative prophylactic application of antibiotics for surgical patients can significantly reduce the infection rate and the levels of inflammatory factors,promote wound healing,shorten the rehabilitation time,and improve treatment satisfaction.It has a positive significance for the improvement of the prognosis,which is worthy of clinical application and promotion.
作者
刘朝
赵虎功
刘强
LIU Chao;ZHAO Hugong;LIU Qiang(Traditional Chinese Medicine Hospital of Gaoling District of Xi'an,Xi'an 710200;Yiyang Central Hospital,Yiyang 413000,China)
出处
《临床医学研究与实践》
2022年第24期58-61,共4页
Clinical Research and Practice
关键词
手术切口
感染预防
抗生素
围术期
住院时间
切口愈合
治疗满意度
surgical incision
infection prevention
antibiotics
perioperative period
hospital stay
wound healing
treatment satisfaction
