摘要
类淋巴系统首次于中枢神经系统研究中提出,后被证实在眼中发挥着清除代谢废物及神经毒性物质的作用。类淋巴系统功能障碍可加重青光眼视网膜中的β-淀粉样蛋白异常沉积,而青光眼视神经筛板结构所处力学环境的异常变化可通过干扰类淋巴系统功能,进一步加重筛板处的轴浆流运输阻滞及代谢物质的清除障碍。筛板处力学环境变化与筛板形态结构密切相关,筛板形变及筛板缺损等异常改变可显著影响类淋巴系统对神经毒性物质的清除效率。类淋巴系统的发现有助于从新的角度重新思考正常眼压青光眼及青光眼进展期患者的视神经损害机制,为青光眼视神经损害机制研究和治疗提供新的方向。
The glymphatic system was firstly proposed in the central nervous system,and then has been proved to function as an eye scavenger of metabolic waste and neurotoxic substances.Recent studies have shown that the dysfunction of glymphatic system can aggravate the retinal deposition of amyloidβ-protein(Aβ)in glaucoma.The abnormal changes of the mechanical environment in optic nerve and lamina cribrosa could interfere the function of glymphatic system,further leading to the block of axoplasmic transport and the obstacle of metabolic clearance in lamina cribrosa.The mechanical environment is firmly related to the structure of lamina cribrosa,lamina cribrosa deformation and defect can significantly affect the clearance efficiency of neurotoxic substances through glymphatic system.The advent of glymphatic system helps to rethink the mechanism of optic nerve damage in normal-tension glaucoma and advanced glaucoma from a new perspective.
作者
程英
王宁利
Cheng Ying;Wang Ningli(Beijing Tongren Eye Center,Beijing Institute of Ophthalmology,Beijing Key Laboratory of Ophthalmology&Visual Sciences,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)
出处
《国际眼科纵览》
2022年第3期193-199,共7页
International Review of Ophthalmology
基金
北京市博士后工作经费资助项目(2021)。
关键词
青光眼
类淋巴系统
废物清除
Β-淀粉样蛋白
跨筛板压力差
glaucoma
glymphatic system
waste removal
amyloidβ-protein(Aβ)
trans-lamina cribrosa pressure difference
