摘要
目的探讨冠脉内注射用尼可地尔联合稳心颗粒对ST段抬高型急性心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)术后围术期主要心血管不良事件(MACE)发生率及相关预后指标的影响。方法选取160例STEMI患者作为研究对象,随机分为对照组、尼可地尔组、稳心颗粒组和联合组各40例。比较四组患者PCI术后TIMI血流分级、术后校正的TIMI血流帧数、心功能指标[包括术后24 h肌钙蛋白I(cTn I)、肌酸激酶同工酶(CK-MB)峰值]、围术期(7 d)MACE事件的发生情况。结果对照组、尼可地尔组、稳心颗粒组和联合组住院期间MACE发生率分别为47.5%、30.0%、30.0%和22.5%,其中联合组术后围术期再灌注心律失常发生率低于对照组和尼可地尔组(P<0.05)。联合组无复流/慢复流发生率和cTn I峰值低于对照组和稳心颗粒组(P<0.05),CK-MB峰值低于对照组(P<0.05),cTFC低于对照组、稳心颗粒组和尼可地尔组(P<0.05)。结论冠脉内注射用尼可地尔联合稳心颗粒能减轻围术期心肌缺血损伤,有效降低STEMI患者PCI术后围术期再灌注心律失常发生率。
Objective To investigate the effect of nicorandil combined with Wenxin granules for intracoronary injection on the incidence of perioperative major adverse cardiovascular events(MACE)and related prognostic indicators in patients with ST segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods 160 STEMI patients were selected as the research subjects,and they were randomly divided into control group,nicorandil group,Wenxin granule group and combination group,with 40 cases in each group.The TIMI blood flow grading,postoperative corrected TIMI blood flow frame number,cardiac function indexes(including 24-hour postoperative cTnI,CK-MB peak value)and the occurrence of perioperative(7 d)MACE events were compared among the four groups of patients condition.Results The incidence of MACE during hospitalization in the control group,nicorandil group,Wenxin granule group and combination group were 47.5%,30.0%,30.0%and 22.5%,respectively,and the incidence of postoperative perioperative reperfusion arrhythmia in the combination group was lower in the control group and nicorandil group(P<0.05).The incidence of no-reflow/slow-reflow and the peak value of cTn I in the combination group were lower than thatose in the control group and Wenxin granule group(P<0.05),the peak value of CK-MB was lower than that in the control group(P<0.05),and the cTFC was lower than that in the control group,Wenxin granule group and nicorandil group(P<0.05).Conclusion Intracoronary injection of nicorandil combined with Wenxin granules can reduce perioperative myocardial ischemia injury and effectively reduce the incidence of perioperative reperfusion arrhythmia in STEMI patients after PCI.
作者
卢昊阳
戎成振
肖慧
薛阳诚
代曼玉
贾卓然
陈刚
赵韧
Lu Haoyang;Rong Chengzhen;Xiao Hui;Xue Yangcheng;Dai Manyu;Jia Zhuoran;Chen Gang;Zhao Ren(Dept of Cardiology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Dept of Cardiology,Fuyang Second People’s Hospital,Fuyang 236000)
出处
《安徽医科大学学报》
CAS
北大核心
2022年第8期1323-1327,共5页
Acta Universitatis Medicinalis Anhui
基金
安徽省高校自然基金重点项目(编号:KJ2014A122)
阜阳市卫生健康委科研立项课题(编号:FY2019-059)。
