摘要
目的:探讨泼尼松与地屈孕酮联用对复发性流产患者的疗效,并分析对血清LP、ADPN水平的影响。方法:选取2020年1月-2021年1月于华中科技大学协和深圳医院接受治疗的复发性流产患者共100例,随机将100例复发性流产患者分为对照组(n=50)和研究组(n=50),其中对照组给予地屈孕酮片治疗,研究组在对照组基础上加用泼尼松片治疗。比较两组治疗前后β-人绒毛膜促性腺激素(β-hCG)、瘦素(LP)和脂联素(ADPN)水平及Th1与Th2细胞因子水平,并统计两组并发症的发生情况。患者出院后随访至2022年4月,了解患者出院后的妊娠及分娩情况。结果:两组的β-hCG、LP和ADPN水平较治疗前均上升(P<0.05),且研究组治疗后的β-hCG、LP和ADPN水平显著高于对照组(P<0.05);两组患者的血清γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)和白细胞介素-2(IL-2)水平较治疗前均下降(P<0.05),而白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)水平较治疗前均升高(P<0.05);研究组IFN-γ、TNF-α和IL-2水平均低于对照组(P<0.05),IL-4、IL-6、IL-10水平均高于对照组(P<0.05);研究组并发症发生率显著低于对照组(P<0.05);研究组再次流产率低于对照组(P<0.05),足月妊娠和成功分娩率显著高于对照组(P<0.05)。结论:采用泼尼松联合地屈孕酮治疗复发性流产可显著提升患者LP、ADPN水平,促进β-hCG生成,改善妊娠结局,值得临床推广。
Objective:To investigate the efficacy of Prednisone combined with Dydrogesterone in the treatment of patients with recurrent spontaneous abortion,and to analyze the influence on levels of serum LP and ADPN.Method:A total of 100 patients with recurrent abortion who were treated in Huazhong University of Science and Technology Union Shenzhen Hospital from January 2020 to January 2021 were selected,and the 100 patients with recurrent abortion were randomly divided into the control group(n=50)and the study group(n=50).The control group was treated with Dydrogesterone Tablets,and the study group was treated with Prednisone Tablets on the basis of the control group.The levels of β-human chorionic gonadotropin(β-hCG),leptin(LP)and adiponectin(ADPN)and the levels of Th1 and Th2 cytokines in the two groups before and after treatment were compared,and the incidence of complications in the two groups was counted.The patients were followed up until April 2022 to understand the pregnancy and childbirth status of the patients after discharge.Result:The levels of β-hCG,LP and ADPN in both groups were higher than those before treatment(P<0.05),and the levels of β-hCG,LP and ADPN in the study group after treatment were significantly higher than those in the control group(P<0.05).The levels of serum γ-interferon(IFN-γ),tumor necrosis factor-α(TNF-α)and interleukin-2(IL-2)were all decreased compared with those before treatment(P<0.05),while the levels of interleukin-4(IL-4),interleukin-6(IL-6)and interleukin-10(IL-10)were increased compared with those before treatment(P<0.05).The levels of IFN-γ,TNF-α and IL-2 in the study group were lower than those in the control group(P<0.05),while the levels of IL-4,IL-6 and IL-10 in the study group were higher than those in the control group(P<0.05).The incidence of complications in the study group was significantly lower than that in the control group(P<0.05).The re-abortion rate in the study group was significantly lower than that in the control group(P<0.05),while the full-term pregnancy and successful delivery rates were significantly higher than those in the control group(P<0.05).Conclusion:Prednisone combined with Dydrogesterone in the treatment of recurrent spontaneous abortion can significantly increase the levels of LP and ADPN,promote the production of β-hCG,and improve pregnancy outcomes,which is worthy of clinical promotion.
作者
王彩
王中海
镇春
谢红艳
WANG Cai;WANG Zhonghai;ZHEN Chun;XIE Hongyan(Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen 524000,China;不详)
出处
《中外医学研究》
2022年第21期48-52,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
泼尼松
地屈孕酮
复发性流产
瘦素
脂联素
Prednisone
Dydrogesterone
Recurrent spontaneous abortion
Leptin
Adiponectin
