摘要
肝纤维化是肝脏对各种急慢性肝损伤进行的一种创伤修复过程,以细胞外基质的过度增生与异常沉积为主要病理特征,其持续发展会恶化为肝硬化、肝癌等疾病。肝纤维化具有可逆性,减轻或逆转肝纤维化被认为是预防肝硬化、肝癌的重要手段。研究表明,黄酮类成分具有抗肝纤维化的作用,其作用机制与抗炎、抗氧化应激、抗凋亡、抑制细胞外基质的异常堆积等有关。黄酮类成分通过多通路、多靶点减轻或逆转肝纤维化进程,近年来备受学者重视。对近10年来国内外报道的具有抗肝纤维化活性的黄酮类成分及其作用机制进行总结,以期为开发黄酮类抗肝纤维化药物提供参考。
Hepatic fibrosis is a wound repair process carried out by the liver for various acute and chronic hepatic injuries.The main pathological features are excessive proliferation and abnormal deposition of extracellular matrix.Its continuous development will deteriorate into hepatic cirrhosis,hepatic carcinoma and other diseases.Hepatic fibrosis is reversible,and alleviating or reversing hepatic fibrosis is considered an important means to prevent hepatic cirrhosis and hepatic cancer.Studies have shown that a variety of flavonoids have anti-hepatic fibrosis effects,and their mechanisms are related to anti-inflammation,anti-oxidative stress,anti-apoptosis,and inhibiting abnormal accumulation of extracellular matrix.Flavonoids reduce or reverse the process of hepatic fibrosis through multiple pathways and multiple targets,and have received much attention from scholars in recent years.Flavonoids with anti-hepatic fibrosis activities and their mechanism of action reported at home and abroad in the past ten years were summarized in this paper,in order to provide reference for development of anti-hepatic fibrosis flavonoid drugs.
作者
马婷
邝晓岚
蔡婉娜
刘博
徐方方
MA Ting;KUANG Xiao-lan;CAI Wan-na;LIU Bo;XU Fang-fang(The Second Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第13期4146-4161,共16页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(82173700)
国家自然科学基金资助项目(81703379)
广州市科技局项目(202102021213)
广东省科技计划项目(2018B020207008)
广州市重点实验室项目(202002010004)。
关键词
黄酮类成分
肝纤维化
作用机制
信号通路
抗炎
抗氧化应激
抗凋亡
flavonoids
hepatic fibrosis
mechanism
signal pathway
anti-inflammation
anti-oxidative stress
anti-apoptosis
