摘要
目的:探讨磷酸奥司他韦治疗儿童流感的效果及对C反应蛋白(CRP)、α_(1)抗胰蛋白酶(α_(1)-AT)、α_(1)酸性糖蛋白(α_(1)-AG)等的影响。方法:选取2017年1月-2022年1月佳木斯市妇幼保健院收治的80例流感患儿,应用随机数字表法分为A组(n=40)及B组(n=40)。B组接受对症支持治疗基础上的利巴韦林治疗,A组在B组基础上加用磷酸奥司他韦。比较两组急性时相反应蛋白水平、白介素水平、临床症状、治疗总有效率及不良反应发生情况。结果:治疗前,两组CRP、α_(1)-AT、α_(1)-AG、白介素-4(IL-4)、白介素-6(IL-6)及白介素-8(IL-8)指标水平比较,差异均无统计学意义(P>0.05);治疗后,两组CRP、α_(1)-AT、α_(1)-AG、IL-4、IL-6、IL-8均低于治疗前,且A组均低于B组,差异均有统计学意义(P<0.05)。A组咳嗽、咽痛消退时间和退热时间均早于B组,差异均有统计学意义(P<0.05)。A组治疗总有效率为97.5%,高于B组的82.5%,A组不良反应发生率为5.0%,低于B组的20.0%,差异均有统计学意义(P<0.05)。结论:磷酸奥司他韦可减轻流感患儿临床症状,改善炎症反应,效果优异,值得推广。
Objective:To investigate the efficacy of Oseltamivir Phosphate in the treatment of influenza in children and its influence on C reactive protein(CRP),α_(1)-antitrypsin(α_(1)-AT),α_(1)-acid glycoprotein(α_(1)-AG).Method:A total of 80 children with influenza admitted to Jiamusi Maternal and Child Health Hospital from January 2017 to January 2022 were selected,they were divided into group A(n=40)and group B(n=40)according to random number table method.Group B received Ribavirin on the basis of symptomatic supportive therapy and group A was treated with Oseltamivir Phosphate on the basis of group B.The acute phase reaction protein level,interleukin level,clinical symptoms,total effective rate of treatment and the incidence of adverse reactions were compared between the two groups.Result:Before treatment,there were no significant differences in the levels of CRP,α_(1)-AT,α_(1)-AG,interleukin-4(IL-4),interleukin-6(IL-6)and interleukin-8(IL-8)between the two groups(P>0.05).After treatment,CRP,α_(1)-AT,α_(1)-AG,IL-4,IL-6 and IL-8 in both groups were lower than those before treatment,and those in group A were lower than those in group B,the differences were statistically significant(P<0.05).The regression time of cough,pharyngeal pain and antipyretic time in group A were earlier than those in group B,the differences were statistically significant(P<0.05).The total effective rate in group A was 97.5%,which was higher than 82.5%in group B,the incidence of adverse reactions in group A was 5.0%,which was lower than 20.0%in group B,the differences were statistically significant(P<0.05).Conclusion:Oseltamivir Phosphate can reduce the clinical symptoms of children with influenza and improve the inflammatory response,with excellent results,which is worth promoting.
作者
李影明
卢君
LI Yingming;LU Jun(Jiamusi Maternal and Child Health Hospital,Heilongjiang Province,Jiamusi 154000,China;不详)
出处
《中国医学创新》
CAS
2022年第24期120-124,共5页
Medical Innovation of China
基金
黑龙江省卫生健康委立项科研项目(2019-358)。
关键词
磷酸奥司他韦
流感
急性时相反应蛋白
Oseltamivir Phosphate
Influenza
Acute phase reaction protein
