摘要
目的探讨宫腔灌注丹红注射液对血瘀型薄型子宫内膜患者冻融胚胎移植(FET)结局的影响。方法选择接受FET治疗的薄型子宫内膜所致不孕症患者66例,采用随机数字表法分为治疗组和对照组,每组33例。患者均于月经第8~10天开始监测卵泡发育,卵泡直径14~18 mm时治疗组使用丹红注射液隔日进行宫腔灌注治疗,同一周期共灌注2~3次,对照组不予任何干预。比较治疗后2组注射人绒毛膜促性腺激素(HCG)日子宫内膜厚度、子宫内膜血流类型、活产率、β-HCG阳性率、临床妊娠率、持续妊娠率、早期流产率、周期取消率以及胚胎种植率。结果治疗组活产率、β-HCG阳性率及持续妊娠率优于对照组,且治疗组HCG日子宫内膜厚度和子宫内膜血流类型优于对照组,差异有统计学意义(P<0.05)。2组患者周期取消率、胚胎种植率、早期流产率、临床妊娠率差异无统计学意义(P>0.05)。结论宫腔灌注丹红注射液可改善薄型子宫内膜患者FET后的妊娠结局,且安全性良好。
Objective To investigate the effect of intrauterine infusion of danhong injection on the outcome of freeze thawing embryo transfer(FET)in patients with thin endometrium caused by blood stagnation.Methods Sixty-six patients with infertility caused by thin endometrium and treated with FET were enrolled and randomly divided into the treatment group and the control group by random number table method,with 33 cases in each group.In the treatment group,follicular development was monitored from the day 8 to 10 of menstrual cycle,and danhong injection was used for intrauterine infusion every other day when the follicle diameter reached 14 mm to 18 mm.A total of 2-3 times of treatment were performed,while no intervention was given to the control group.After treatment,the endometrial thickness,endometrial blood flow type,live birth rate,positive rate ofβ-HCG,clinical pregnancy rate,ongoing pregnancy rate,early abortion rate,cycle cancellation rate and embryo implantation rate on human chorionic gonadotropin(HCG)injection day were compared between the two groups.Results The live birth rate,positive rate ofβ-HCG and persistent pregnancy rate were significantly better in the treatment group than those in the control group,and the endometrial thickness and endometrial blood flow type on ovulation day were significantly better in the treatment group than those in the control group(P<0.05).There were no significant differences in cycle cancellation rate,embryo implantation rate,early abortion rate and clinical pregnancy rate between the two groups(P>0.05).Conclusion Intrauterine infusion of danhong injection can improve pregnancy outcome in patients with thin endometrium with good safety.
作者
董融
王宝娟
马赛花
张玙
邱韵桓
夏天
DONG Rong;WANG Baojuan;MA Saihua;ZHANG Yu;QIU Yunhuan;XIA Tian(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncuture and Moxibustion,Tianjin 300381,China)
出处
《天津医药》
CAS
北大核心
2022年第9期970-974,共5页
Tianjin Medical Journal
基金
天津市教委科研计划项目(2019KJ047)。
关键词
灌流
丹参
红花
注射剂
子宫内膜
丹红注射液
薄型子宫内膜
子宫内膜容受性
perfusion
salvia miltiorrhiza
carthamus tinctorius
injectio
endometrium
thin endometrium
danhong injection
endometrial receptivity
