摘要
目的探讨血清半乳糖凝集素-9(Galectin-9)和程序性死亡受体-配体1(PD-L1)对慢性乙型肝炎(CHB)肝脏炎症程度的诊断价值。方法选取2020年1月至2021年7月周口市疾控中心专科病医院CHB患者126例为观察组,同期选取45名健康体检者为对照组。比较两组临床特征及血清Galectin-9、PD-L1水平,CHB患者血清Galectin-9、PD-L1水平与临床特征相关性,Logistic回归分析CHB患者显著肝脏炎症影响因素,受试者工作特征(ROC)分析血清Galectin-9、PD-L1对CHB患者肝脏炎症程度的诊断价值。结果观察组血清Galectin-9、PD-L1水平高于对照组,差异有统计学意义(t=19.108,21.523,P<0.05);CHB患者血清Galectin-9、PD-L1水平与HBV-DNA、炎症分级、纤维化分期均呈正相关(P<0.05);Logistic回归模型分析显示,HBV-DNA及血清Galectin-9、PDL1水平升高均为CHB患者显著肝脏炎症独立危险因素(P<0.05);ROC显示,Galectin-9、PD-L1联合诊断肝脏炎症程度的AUC值0.850最大,对应敏感度为85.96%,特异度为72.46%,优于单一诊断(P<0.05)。结论CHB患者血清Galectin-9、PD-L1异常高表达,且可较准确地诊断肝脏炎症程度,利于监测CHB疾病进展。
Objective To investigate the diagnostic value of serum galectin-9(Galectin-9)and programmed death-ligand 1(PD-L1)in the degree of liver inflammation in chronic hepatitis B(CHB).Methods From January 2020 to July 2021,126 CHB patients in Zhoukou CDC Specialized Disease Hospital were selected as the observation group,and 45 healthy subjects were selected as the control group during the same period.The clinical characteristics and serum Galectin-9 and PD-L1 levels of the two groups were compared,and the correlation between serum Galectin-9 and PD-L1 levels and clinical characteristics in CHB patients was compared.The ROC curve was drawn to analyze the diagnostic value of serum Galectin-9 and PD-L1 on the degree of liver inflammation in CHB patients.Results Serum Galectin-9 and PD-L1 levels in the observation group were higher than those in the control group(t=19.108,21.523,P<0.05).Serum Galectin-9 and PD-L1levels in CHB patients were positively correlated with HBV-DNA,inflammation grade and fibrosis stage(P<0.05).Logistic regression model analysis showed that HBV-DNA and increased serum Galectin-9 and PD-L1levels were independent risk factors for significant liver inflammation in CHB patients(P<0.05).The ROC curve results showed that the AUC value of Galectin-9 and PD-L1 in the diagnosis of liver inflammation was the highest at 0.850,with a corresponding sensitivity of 85.96%and a specificity of 72.46%,which were better than single diagnosis(P<0.05).Conclusion Sserum Galectin-9 and PD-L1 levels in CHB patients are abnormally high,and can more accurately diagnose the degree of liver inflammation,which is conducive to monitoring the progression of CHB disease.
作者
贾梦山
刘加敏
杨艳霞
JIA Mengshan;LIU Jiamin;YANG Yanxia(Department of Hepatology,Zhoukou Hospital for Disease Control and Prevention,Zhoukou,Henan,China,466000)
出处
《分子诊断与治疗杂志》
2022年第8期1354-1357,1362,共5页
Journal of Molecular Diagnostics and Therapy
基金
河南科技厅重点项目(20200725)。
