摘要
目的:分析内镜逆行胰胆管造影术(ERCP)应用奥曲肽对术后高淀粉酶血症和急性胰腺炎发生的预防效果。方法:采用随机数字分配法将60例2018年9月至2021年10月德兴市人民医院收治的行ERCP治疗的患者分为研究组、对照组各30例。对照组予以抗感染、抑酸治疗,研究组在对照组的基础上加用奥曲肽治疗,两组均观察至出院。比较两组治疗后的临床疗效,住院总费用、平均住院日,术前、术后3 h,术后6 h全血血糖、血清淀粉酶水平,术后并发症发生情况。结果:治疗后,研究组总有效率高于对照组(P<0.05)。研究组住院总费用少于对照组,平均住院日短于对照组(P<0.05)。治疗前、术后3 h、术后6 h,两组全血血糖、血清淀粉酶呈先上升,再下降趋势,且术后3 h、术后6 h,研究组血清淀粉酶水平低于对照组(P<0.05)。术后,研究组高淀粉酶血症、急性胰腺炎发生率低于对照组(P<0.05),研究组、对照组腹胀、恶心呕吐发生率比较,差异无统计学意义(P>0.05)。结论:奥曲肽可降低行ERCP术治疗的患者血清淀粉酶水平,降低患者发生急性胰腺炎、高淀粉酶血症的风险,进而可缩短患者住院时间,减轻患者治疗负担,有较好的治疗效果。
Objective:To analyze the preventive effect of octreotide on hyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP).Methods:60 patients with ERCP admitted to the Dexing People’s Hospital from September 2018 to October 2021 were divided into the study group and the control group,30 cases in each group.The control group was treated with anti-infection and acid inhibition.The study group was treated with octreotide on the basis of the control group.The total cost of hospitalization,the average length of stay,the level of blood glucose,serum amylase and postoperative complications were compared between the two groups.Results:After treatment,the total effective rate of the study group was higher than that of the control group(P<0.05).The total cost of hospitalization in the study group was less than that in the control group,and the average length of hospitalization was shorter than that in the control group(P<0.05).Before treatment,3 h after operation and 6 h after operation,blood glucose and serum amylase in the two groups increased first,then decreased,and the level of serum amylase in the study group was lower than that in the control group(P<0.05).After operation,the incidence of hyperamylasemia and acute pancreatitis in the study group was lower than that in the control group(P<0.05),there was no significant difference in the incidence of abdominal distention,nausea and vomiting between the study group and the control group(P<0.05).Conclusion:Octreotide could reduce the serum level of amylase and the risk of acute pancreatitis,hyperamylasemia in patients undergoing ERCP,so as to shorten the hospitalization time and reduce the treatment burden.
作者
叶孟华
YE Menghua(Dexing People's Hospital,Dexing Jiangxi 334200,China)
出处
《药品评价》
CAS
2022年第11期670-672,共3页
Drug Evaluation
关键词
胰胆管造影术
内窥镜逆行
奥曲肽
手术后并发症
高淀粉酶血症
急性胰腺炎
预防
淀粉酶
Cholangiopancreatography
endoscopic retrograde
Octreotide
Postoperative complications
Hyperamylasemia
Acute pancreatitis
Prophylaxis
Amylase
