摘要
中风是全球死亡和残疾的主要原因,开发增强中风后恢复和增强神经修复的方法至关重要。中风后的恢复涉及复杂的相互关联的神经修复系统。神经修复整个过程需要神经元胞体对伤害性刺激作出应答,通过神经干细胞增殖与迁移、轴浆运输信号分子、细胞骨架结构构建以及轴突末端生长锥形成等一系列协调的相互作用,才能实现再生生长。神经功能重塑作为神经功能缺损治疗潜在的新靶点,无论是神经功能重塑的具体机制,还是神经功能缺损临床治疗方案,均具有重要研究意义。脑损伤后,由于其内在修复机制十分复杂,单一的治疗措施时常难以奏效,综合治疗将是提高脑内再修复功能的发展方向。益气活血法具有神经保护、血管再生、神经发生及环路重建等多方面生物效应,可共同促进损伤后的神经功能重塑;其作用机制与细胞自噬、免疫调节及微小RNA调控密切相关,充分体现了益气活血法的多途径、多靶点、整体调节的治疗特点以及对中风后的神经修复发挥重要的治疗作用。因此,进行益气活血法对中风后脑功能康复的研究具有十分重要的理论和指导意义。
Stroke is the leading cause of death and disability.Therefore,it is critical to develop the approaches for improving recovery and neural repair after stroke.Recovery after stroke involves complex interrelated systems of neural repair.The whole process of neural repair requires a series of coordinated interactions,such as response of neuronal cell body to traumatic stimuli,neural stem cell proliferation and migration,axoplasmic transport of signaling molecules,construction of cytoskeleton,and formation of axonal growth cone,to achieve regeneration and growth.As a potential new target for the treatment of neurologic defects,neural remodeling has important research significance in both the specific mechanism of neural repair and the clinical treatment of neurologic defects.After brain injury,single therapy is often ineffective due to the complex mechanism of internal repair,and thus comprehensive therapy becomes the development direction to improve the brain repair.Invigorating qi and promoting blood can promote nerve function remodeling after injury through neural protection,angiogenesis,neurogenesis,loop reconstruction,and cytokine regulation,playing a key role in nerve repair after stroke.Its mechanism is associated with autophagy,immunomodulation,and microRNA regulation,which fully embodies the multi-pathway,multi-target,and overall regulation characteristics of invigorating Qi and activating blood.Therefore,it is of theoretical and guiding significance to study the brain function rehabilitation after stroke by invigorating qi and activating blood.
作者
范晓迪
张业昊
刘建勋
FAN Xiaodi;ZHANG Yehao;LIU Jianxun(Beijing Key Laboratory of Pharmacology of Chinese Materia Medica,Institute of Basic Medical Sciences,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第15期216-222,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(82104444,8203000944)
中国中医科学院科技创新工程项目(CI2021A04617,CI2021A01304)
中国中医科学院西苑医院国家自然科学基金培育项目(XY20-04)。
关键词
缺血性中风
神经修复
气虚血瘀证
益气活血法
生物学基础
ischemic stroke
neural repair
syndrome of Qi deficiency and blood stasis
invigorating qi and activating blood
biological basis
