摘要
目的 研究在阿卡波糖治疗的基础上增用甘精胰岛素治疗2型糖尿病(diabetes mellitus type 2,T2DM)的疗效及安全性。方法 选择深圳市第二人民医院2019年10月—2021年10月收治的82例T2DM患者,以随机双盲对照法将其分成联合组及对照组,各41例。对照组的治疗方式包括饮食、运动干预及阿卡波糖治疗。联合组则在对照组的基础上同时增用甘精胰岛素治疗。对比两组血糖指标、应激反应指标以及炎症因子水平变化情况,不良反应发生情况。结果 治疗后联合组空腹血糖(FPG)、餐后2 h血糖(2 hPG)以及糖化血红蛋白水平均低于对照组,差异有统计学意义(P<0.05)。治疗后联合组血清丙二醛(MDA)水平均高于对照组,而超氧化物歧化酶(SOD)水平低于对照组,差异有统计学意义(P<0.05)。治疗后联合组血清C反应蛋白(CRP)以及白细胞介素-6(IL-6)水平均低于对照组,差异有统计学意义(P<0.05)。两组胃肠不适、一过性视力障碍以及低血糖发生率对比,差异无统计学意义(P>0.05)。结论 在阿卡波糖治疗的基础上增用甘精胰岛素对T2DM患者的疗效显著,可在一定程度上改善机体应激反应程度以及炎症因子水平,且不会增加不良反应发生风险。
Objective To study the efficacy and safety of intervening in the treatment of type 2 diabetes mellitus(T2 DM) with the addition of insulin glargine to the treatment of acarbose.Methods A total of 82 T2 DM patients admitted to Shenzhen Second People’s Hospital from October 2019 to October 2021 were divided into combined group and control group by randomized double-blind control method,with 41 cases in each group.The control group was treated with diet,exercise intervention and acarbose.The combined group was additionally treated with insulin glargine.The levels of blood glucose,stress response and inflammatory factors and the occurrence of adverse reactions were compared between the two groups.Results After treatment,fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG) and glycosylated hemoglobin levels in the combined group were lower than those in the control group,the differences were statistically significant(P0.05).Conclusion On the basis of acarbose treatment,the addition of insulin glargine has a significant effect on patients with T2 DM,which can improve the degree of stress response and the level of inflammatory factors in the body to a certain extent,without increasing the risk of adverse reactions.
作者
陈钦榜
何英
CHEN Qinbang;HE Ying(Department of Pharmacy,Shenzhen Second People's Hospital,Shenzhen,Guangdong Province,518025 China)
出处
《糖尿病新世界》
2022年第13期81-84,共4页
Diabetes New World Magazine
