摘要
概述了化妆品安全评估所涉及的化学性风险物质,包括《化妆品安全技术规范》规定的限用、准用物质中的杂质要求,化妆品原料标准和国内外研究、文献所报道的原料中可能存在的风险物质。结果表明准用着色剂中的风险物质较多,而且大多没有相应的检测方法;其他常用原料中可能含有的杂质不少是化妆品中的禁用物质,来源于降解、生产用原料带入、化学反应的副产物等多个途径,目前基本有配套的测定标准或文献方法可供参考。今后随着原料安全评估的深入开展,还会发现越来越多的风险物质,因此建议加强化妆品原料标准尤其是准用着色剂质量标准和所含风险物质检测方法标准的研究,充实化妆品标准体系。
The chemical risk substances involved in the safety assessment of cosmetics were summarized.The requirements for impurities in restricted and approved substances were specified in the“Safety and Technical Standards for Cosmetics”,and the possible risk substances in raw materials in the standards of cosmetics raw materials,domestic and foreign research and literature were presented.It is concluded that many approved colorants contain risk substances,however,there are little detection methods of these impurities.Although there are many product standards of dyes or food additives,no cosmetic raw material standard of approved colorants is released.The quality indicators of most dyes or food additives do not match the requirements of“Safety and Technical Standards for Cosmetics”.It is indicated that many risk substances that may be contained in common raw materials are prohibited substances in cosmetics,which come from degradation,introduction of raw materials,by-products of chemical reaction,et al.Most of these impurities have determination standards or literature testing methods.Since there are no residue requirements in standard or assessment for chlorotoluene,nitromethane and other risk substances which rare prohibited substances in cosmetics,it is necessary to calculate the MoS,LCR or AEL according to their toxicological data and exposure dose during the safety assessment,in order to judge the safety of the product.In the future,with the in-depth development of raw material safety assessment,more and more risk substances would be found.It is suggested to strengthen the research of cosmetics raw materials,especially the quality standards of approved colorants and the detection methods of their risk substances,so as to enrich the system of cosmetics standards.
作者
顾宇翔
杨保刚
陆壹
Yuxiang Gu;Baogang Yang;Yi Lu(Shanghai Institute of Quality Inspection and Technical Research,Shanghai 200233,China)
出处
《日用化学工业》
CAS
北大核心
2022年第9期990-998,共9页
China Surfactant Detergent & Cosmetics
关键词
化妆品
安全评估
风险物质
检测
cosmetics
safety assessment
risk substances
determination
