摘要
目的探讨血尿酸(UA)水平与脑梗死合并精神异常急性期脑血管狭窄的关系。方法选取2020年4月~2021年10月在我院及赣州市人民医院治疗的急性脑梗死(ACI)合并精神异常患者200例,其中初发脑梗死92例,复发脑梗死53例,陈旧性脑梗死55例。比较三组的UA水平、高尿酸血症和血管狭窄程度,分析急性脑梗死合并精神异常患者UA与脑血管狭窄程度、高脂血症、高血压的相关性,分析ACI合并精神异常患者血尿酸分层与脑血管狭窄程度的关系。结果3组患者的UA水平、高尿酸血症与血管狭窄程度比较,差异均无统计学意义(均P>0.05);陈旧性脑梗死组无明显狭窄比例高于复发脑梗死组和初发脑梗死组,重度狭窄比例低于初发脑梗死组和复发脑梗死组,差异均有统计学意义(均P<0.05)。急性脑梗死合并精神异常患者的UA与脑血管狭窄程度、高血压、高脂血症、糖尿病均呈负相关(均P<0.05);多因素分析显示,第一分位UA和高脂血症是ACI合并精神异常脑血管狭窄的高危因素(OR>1,P<0.05)。结论低UA水平可能会增加脑梗死合并精神异常急性期脑血管狭窄发生风险。
Objective To investigate the relationship between serum uric acid(UA)level and cerebral vascular stenosis in acute stage of cerebral infarction complicated with mental disorders.Methods A total of 200 patients with acute cerebral infarction(ACI)complicated with mental disorders who were hospitalized in our hospital and Ganzhou People’s Hospital from April 2020 to October 2021 and were selected,including 92 cases of initial cerebral infarction and 53 cases of recurrent cerebral infarction.55 cases of cerebral infarction.The levels of UA,hyperuricemia and degree of vascular stenosis in the three groups were compared,and the correlation between UA and the degree of cerebral vascular stenosis,hyperlipidemia and hypertension in patients with acute cerebral infarction complicated with mental disorders,as well as the serum uric acid level in patients with ACI complicated with mental disorders were analyzed.The relationship between the layer and the degree of cerebral vascular stenosis.Results There was no significant difference in UA level,hyperuricemia and vascular stenosis among the three groups(P>0.05).The old cerebral infarction group had a higher proportion of no obvious stenosis than those of the recurrent cerebral infarction group and the first cerebral infarction group.The proportion was lower than that of the initial cerebral infarction group and the recurrent cerebral infarction group,with a statistical difference(P<0.05 for both).In patients with acute cerebral infarction combined with mental disorders,UA was negatively correlated with the degree of cerebral vascular stenosis,hypertension,hyperlipidemia and diabetes.Correlation(P<0.05 for each);Multivariate analysis showed that the first quantile UA and hyperlipidemia were independent risk factors for ACI complicated with mental abnormal cerebral vascular stenosis(P<0.05).Conclusion Low UA level may increase the risk of cerebral vascular stenosis in acute stage of cerebral infarction complicated with mental disorders.
作者
何著发
钟海龙
任优梅
彭金亮
郭树平
HE Zhu-fa;ZHONG Hai-long;REN You-mei;PENG Jin-liang;GUO Shu-ping(The Third People's Hospital of Ganzhou,Ganzhou City,Jiangxi Province,341000,China;Ganzhou People's Hospital,Ganzhou City,Jiangxi Province,341000,China)
出处
《蛇志》
2022年第3期329-331,357,共4页
Journal of Snake
基金
赣州市指导性科技计划项目(项目名称:血尿酸水平与脑梗死合并精神异常急性期脑血管狭窄的关系,项目编号:GZ2020ZSF272)。
关键词
脑梗死
精神异常
脑血管狭窄
血尿酸
Cerebral infarction
Mental disorders
Cerebral vascular stenosis
Serum uric acid
