摘要
目的对比经尿道膀胱肿瘤等离子电切术(TURBT)与经尿道膀胱肿瘤钬激光剜除术(HoLRBT)治疗膀胱肿瘤的近期疗效及术后复发情况。方法回顾性分析2018年6月至2019年6月在本院治疗的102例膀胱肿瘤患者的临床资料,其中51例患者行TURBT治疗(T组),51例患者行HoLRBT治疗(H组)。比较两组的手术时间、膀胱冲洗时间、术中出血量、术后肿瘤危险度分级、并发症发生率、术后1年复发率等。结果与T组比较,H组的手术时间、膀胱冲洗时间、尿管留置时间、住院时间更短,术中出血量更少,差异均有统计学意义(均P<0.05)。T组的闭孔神经反射、膀胱穿孔发生率及并发症总发生率均高于H组(均P<0.05)。两组术后的肿瘤危险度比较,差异无统计学意义(P>0.05)。H组术后1年的p53蛋白阳性率、Ki-67蛋白阳性率均低于T组(均P<0.05)。H组的肿瘤复发率低于T组(5.88%vs.15.69%,P<0.05)。结论TURBT和HoLRBT均是治疗膀胱肿瘤的有效手段,疗效相当,但后者的手术时间更短、术后并发症更少,且术后1年的复发风险更低,临床应用优势更显著。
Objective To compare the short-term efficacy and postoperative recurrence of transurethral plasma resection of bladder tumor(TURBT)and transurethral holmium laser enucleation of bladder tumor(HoLRBT)in the treatment of bladder cancer.Methods The clinical data of 102 patients with bladder tumors treated in our hospital from June 2018 to June 2019 were retrospectively analyzed.Among them,51 patients underwent TURBT(group T)and 51 patients underwent HoLRBT(group H).The operation time,bladder irrigation time,intraoperative blood loss,postoperative tumor risk grade,complication rate,and 1-year postoperative recurrence rate were compared between the two groups.Results Compared with group T,the operation time,bladder irrigation time,catheter indwelling time,hospital stay and intraoperative blood loss in group H were shorter,and the differences were statistically significant(P<0.05).The incidence of obturator nerve reflex,bladder perforation and total incidence of complications in group T were higher than those in group H(all P<0.05).There was no significant difference in postoperative tumor risk between the two groups(P>0.05).The positive rates of p53 protein and Ki-67 protein in group H at 1 year after operation were lower than those in group T(all P<0.05).The tumor recurrence rate in group H was lower than that in group T(5.88%vs.15.69%,P<0.05).Conclusions TURBT and HoLRBT are effective methods for the treatment of bladder cancer,and the curative effect of the two methods is similar,but the latter has shorter operation time,fewer postoperative complications and lower risk of recurrence 1 year after operation.
作者
王振誉
郑兵
朱华
张冰
顾栋华
Wang Zhenyu;Zheng Bing;Zhu Hua;Zhang Bing;Gu Donghua(Department of Urology,Nantong First People's Hospital,Nantong 226000,China)
出处
《国际泌尿系统杂志》
2022年第5期811-814,共4页
International Journal of Urology and Nephrology
基金
南通市卫生和计划生育委员会科研课题(QA2019012)
南通市基础科学研究和社会民生计划课题编号(JCZ2022075)。
关键词
膀胱肿瘤
经尿道膀胱肿瘤切除术
双极等离子
激光
固体
Urinary Bladder Neoplasms
Transurethral Resection of Bladder Tumor
Bipolar Plasma
Lasers,Solid-State
