摘要
目的比较“清消法”与“温消法”两种方法治疗肉芽肿性小叶性乳腺炎的临床疗效。方法纳入2019年5月—2019年9月就诊于上海中医药大学附属龙华医院经病理确诊为肉芽肿性小叶性乳腺炎的患者共计68例,采用前瞻性、随机、对照的方式,按1∶1的比例随机纳入“清消组”或“温消组”。观察时间为6个月,比较两组的治愈率、治愈时间及肿块表面积,并作安全性评价。结果清消组34例,剔除1例,脱落1例,完成32例;温消组34例,剔除2例,脱落4例,完成28例。清消组6个月治愈20例(62.5%),好转11例(34.38%),无效1例(3.13%),总有效率96.88%(31/32)。温消组6个月治愈16例(57.14%),好转12例(42.86%),无效0例(0),总有效率100%(28/28)。“清消组”在治疗第2、3、4、6个月的治愈率均高于“温消组”,在治疗第4个月“清消组”治愈率高于“温消组”,差异有统计学意义(P<0.05);治疗第3、4个月时“清消组”肿块面积小于“温消组”,差异有统计学意义(P<0.05);观察期6个月结束时,两组治愈率、治愈时间、肿块面积差异无统计学意义(P>0.05)。两组治疗期间均无明显的不良反应。结论“清消法”与“温消法”在治疗肉芽肿性小叶性乳腺炎均有安全、可靠疗效,且可以很好地保留乳房外形;在观察前期“清消法”较“温消法”在治愈率、肿块消散方面有明显优势。
Objective To compare the clinical efficacy of“clearing-eliminating method”and“warming-eliminating method”in the treatment of granulomatous lobular mastitis.Methods A total of 68 patients with pathologically diagnosed as granulomatous lobular mastitis who visited Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from May 2019 to September 2019 were included in a prospective,randomized and controlled manner,and were randomly included in the“clearing-eliminating method group”or“warming-eliminating method group”in a ratio of 1∶1.The observation time was 6 months.The cure rate,cure time and mass surface area of the two groups were compared,and the safety was evaluated.Results In the clearing-eliminating method group(34 cases),1 case was excluded,1 case was fell off,and 32 cases were completed the study.Among 34 cases in the warming-eliminating method group,2 cases were removed,4 cases were exfoliated,and 28 cases were completed the study.In the clearing-eliminating method group,20 cases(62.5%)were cured,11 cases(34.38%)were improved and 1 case(3.13%)was ineffective.The total effective rate was 96.88%(31/32).In the warming-eliminating method group,16 cases(57.14%)were cured,12 cases(42.86%)were improved and 0 case(0)was ineffective,and the total effective rate was 100%(28/28).The cure rate of clearing-eliminating method group was higher than that of warming-eliminating method group at 2,3,4 and 6 months after treatment,and the cure rate of clearing-eliminating method group was higher than that of warming-eliminating method group at 4 months after treatment,the difference was statistically significant(P<0.05).At the 3 rd and 4 th month of treatment,the mass area of the clearing-eliminating method group was smaller than that of the warming-elimination group with statistical significance(P<0.05).At the end of the observation period of 6 months,there was no significant difference in cure rate,cure time or mass area between the two groups(P>0.05).There were no obvious toxic or side effects in the two groups during treatment.Conclusion Both clearing-eliminating method and warming-eliminating method have safe and reliable efficacy in the treatment of granulomatous lobular mastitis,and can preserve the breast shape well.In the observation of the early stage,clearing-eliminating method has obvious advantages over warming-eliminating method in terms of cure rate and mass dissipation.
作者
耿金珠
热孜亚
孙霃平
刘胜
GENG Jinzhu;RE Ziya;SUN Chenping;LIU Sheng(The Second Hospital of TCM in Kaifeng,Kaifeng 475000,Henan,China;Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《辽宁中医杂志》
CAS
2022年第8期148-152,共5页
Liaoning Journal of Traditional Chinese Medicine
关键词
肉芽肿性小叶性乳腺炎
清消法
温消法
中医药治疗
granulomatous lobular mastitis
clearing-eliminating method
warming-eliminating method
Chinese medicine treatment
