摘要
目的分析急性心肌梗死患者经皮冠状动脉介入治疗(PCI)术后应用替格瑞洛与氯吡格雷的效果。方法94例接受PCI术治疗的急性心肌梗死患者,采用随机数字表法分为对照组和观察组,各47例。对照组接受氯吡格雷治疗,观察组接受替格瑞洛治疗。比较两组治疗效果、心功能指标、治疗前后的肝功能指标、肾功能指标、C反应蛋白(CRP)水平、不良反应发生率。结果观察组治疗总有效率为97.87%,高于对照组的82.98%,差异有统计学意义(P<0.05)。观察组每搏输出量(SV)、左室射血分数(LVEF)分别为(92.62±9.08)ml、(49.01±4.73)%均大于对照组的(87.54±8.49)ml、(44.56±4.25)%,左室舒张期末内径(LVEDD)、左室收缩期末容积(LVESV)分别为(60.03±5.82)mm、(75.58±7.37)ml,均小于对照组的(64.72±6.25)mm、(80.28±7.81)ml,差异有统计学意义(P<0.05)。治疗后,两组谷草转氨酶(AST)、血清肌酐(Scr)均较治疗前升高,CRP均较治疗前降低,且观察组AST(28.15±2.64)IU/L、Scr(121.38±11.92)μmol/L高于对照组的(25.08±2.37)IU/L、(115.74±11.27)μmol/L,CRP(5.82±0.55)mg/L低于对照组的(9.97±0.96)mg/L,差异有统计学意义(P<0.05)。观察组不良反应发生率为4.26%,低于对照组的19.15%,差异有统计学意义(P<0.05)。结论急性心肌梗死患者在PCI术后接受替格瑞洛治疗,可以有效改善患者的心功能,并且治疗时的不良反应较少,治疗效果良好,值得在临床上推广应用。
Objective To analyze the effect of ticagrelor and clopidogrel in patients with acute myocardial infarction after percutaneous coronary intervention(PCI).Methods A total of 94 patients with acute myocardial infarction after PCI were divided into control group and observation group by random numerical table,with 47 cases in each group.The control group was treated with clopidogrel,and the observation group was treated with ticagrelor.The therapeutic effect,cardiac function index,liver function index,renal function index,C-reactive protein(CRP)level before and after treatment,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.87%,which was higher than 82.98%of the control group,and the difference was statistically significant(P<0.05).The stroke volume(SV)and left ventricular ejection fraction(LVEF)in the observation group were(92.62±9.08)ml,(49.01±4.73)%,which were greater than(87.54±8.49)ml and(44.56±4.25)%in the control group;the left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic volume(LVESV)in the observation group were(60.03±5.82)mm and(75.58±7.37)ml,which were less than(64.72±6.25)mm and(80.28±7.81)ml in the control group;the differences were statistically significant(P<0.05).After treatment,the aspartate transaminase(AST),serum creatinine(Scr)and CRP in both groups were lower than those before treatment in this group;the AST(28.15±2.64)IU/L and Scr(121.38±11.92)μmol/L in the observation group were higher than(25.08±2.37)IU/L and(115.74±11.27)μmol/L in the control group;the CRP(5.82±0.55)mg/L in the observation group was lower than(9.97±0.96)mg/L in the control group;all the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 4.26%,which was lower than 19.15%in the control group,and the difference was statistically significant(P<0.05).Conclusion Ticagrelor has good therapeutic effect on patients with acute myocardial infarction receiving after PCI,and can effectively improve the cardiac function of patients with less adverse reactions,which is worthy of clinical promotion and application.
作者
刘晓明
LIU Xiao-ming(Department of Cardiovascular Medicine,General Hospital of Ansteel Group Corporation,Anshan 114000,China)
出处
《中国现代药物应用》
2022年第17期107-109,共3页
Chinese Journal of Modern Drug Application
