摘要
目的:探讨艾普拉唑联合抗生素序贯方案应用于慢性萎缩性胃炎(CAG)活动期伴幽门螺杆菌(Hp)感染患者治疗的疗效及对睡眠质量的影响。方法:选取2020年3月至2021年6月东莞市水乡中心医院收治的CAG活动期伴Hp感染患者86例作为研究对象,按照随机摸球法分成观察组和对照组,每组43例。对照组采用抗生素序贯方案治疗,观察组采用艾普拉唑联合抗生素序贯方案治疗,比较2组患者炎症介质、胃肠激素水平、Hp清除率及复发率。结果:治疗后,2组患者白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平均降低(均P<0.05),观察组患者以上炎症介质水平均比对照组更低(均P<0.05);治疗后,2组患者胃肠激素内皮素(ET)、表皮生长因子(EGF)水平均降低(均P<0.05),降钙素基因相关肽(CGRP)水平均升高(均P<0.05),观察组患者ET、EGF水平均比对照组更低(均P<0.05),CGRP水平比对照组患者更高(P<0.05);观察组Hp清除率比对照组更高(P<0.05),复发率更低(P<0.05)。结论:艾普拉唑联合抗生素序贯方案应用于CAG活动期伴Hp感染治疗中,可更好地降低炎症介质水平,更好地改善胃肠激素水平,提高Hp清除率,降低Hp复发率。
Objective:To investigate the efficacy of eprazole combined with antibiotic sequential regimen in the treatment of chronic atrophic gastritis(CAG)patients with Helicobacter pylori(Hp)infection at the active stage and its effect on sleep quality.Methods:A total of 86 patients with active CAG with Hp infection admitted to Dongguan Shuixiang Central Hospital from March 2020 to June 2021 were selected and divided into the observation group(n=43)and the control group(n=43)by the random ball touch method.The control group was treated with antibiotic sequential regimen,and the observation group was treated with eprazole combined with antibiotic sequential regimen.The levels of inflammatory mediators,gastrointestinal hormones,Hp clearance rate and recurrence rate of the two groups were compared.Results:The levels of interleukin-6(IL-6),interleukin-8(IL-8),C-reactive protein(CRP)and tumour necrosis factor-α(TNF-α)were reduced in both groups after treatment(Ps<0.05),and the levels in the observation group were lower than those in the control group(Ps<0.05).The levels of gastrointestinal hormone endothelin(ET)and epidermal growth factor(EGF)were reduced in both groups after treatment(Ps<0.05)and the level of calcitonin generelated peptide(CGRP)increased(P<0.05).The levels of ET and EGF were lower(P<0.05)and the level of CGRP was higher(P<0.05)in the observation group compared with the control group.The clearance rate of Hp was higher(P<0.05)and the recurrence rate was lower(P<0.05)in the observation group compared with the control group.Conclusion:Eprazole combined with antibiotic sequential regimen can improve the levels of inflammatory mediators and gastrointestinal hormones,increase the clearance rate of Hp and reduce the recurrence rate in the treatment of patients with Hp infection at the active stage of CAG.
作者
莫颖娟
周礼志
赖胜华
陈渠发
MO Yingjuan;ZHOU Lizhi;LAI Shenghua;CHEN Qufa(Dongguan Shuixiang Central Hospital,Dongguan 523142,China)
出处
《世界睡眠医学杂志》
2022年第8期1390-1393,共4页
World Journal of Sleep Medicine
关键词
艾普拉唑
抗生素序贯方案
慢性萎缩性胃炎活动期
幽门螺杆菌感染
Eprazole
Sequential antibiotic regimen
Active stage of chronic atrophic gastritis
Helicobacter pylori infection
