摘要
目的探讨高原非原住民高同型半胱氨酸血症(HHcy)危险因素。方法选取2021年5月至7月在某体检中心进行体检的62例男性高原非原住民作为研究对象,收集体检资料,以单因素、多因素二项Logistic回归分析HHcy相关危险因素;以ROC曲线计算海拔拐点值。结果本研究检出HHcy者48例,检出率77.42%;该群体中,驻守地≥4500 m为HHcy的危险因素(OR=3.94,95%CI:1.09,14.14,P<0.05),低水平的T细胞比率可能是保护因素(OR=0.08,95%CI:0.01,0.49,P=0.01);ROC曲线下面积(AUC)为0.70(95%CI:0.53,0.84,P=0.04),海拔高度的拐点值为4550 m。结论来自海拔(4961.44±676.60)m地区的男性高原非原住民,驻守地≥4500 m是HHcy患病最主要的影响因素;其中在驻守地海拔≥4550 m的地区需要特别关注该群体的HHcy防治情况。
Objective To explore the risk factors of hyperhomocysteinemia(HHcy)in non aborigines at high altitude.Methods 62 male plateaunon aborigines who underwent physical examination in a physical examination center from May to July 2021 were selected as the research objects.The physical examination data were collected and the risk factors related to HHcy were analyzed by univariate and multivariate binomial logistic regression,the altitude inflection point value was calculated with ROC curve.Results 48 cases of HHcy were detected in this study,the detection rate was77.42%;In this population,garrison≥4500 m was a risk factor for HHcy(OR=3.94,95%CI:1.09,14.14,P<0.05),and low level of T cell ratio may be a protective factor(OR=0.08,95%CI:0.01,0.49,P=0.01);The area under the ROC curve(AUC)was 0.70(95%CI:0.53,0.84,P=0.04),and the inflection point of altitude was 4550 m.Conclusion For male non aborigines from the altitude of(4961.44±676.60)m,garrison≥4500 m is the main factor affecting the prevalence of HHcy,Among them,special attention should be paid to the prevention and control of HHcy in the area where the altitude of the garrison is≥4550 m.
作者
周晰溪
黄佳琦
裴琼华
赵浩然
王中华
Zhou Xixi;Huang Jiaqi;Pei Qionghua;Zhao Haoran;Wang Zhonghua
出处
《中国疗养医学》
2022年第11期1130-1134,共5页
Chinese Journal of Convalescent Medicine
