摘要
目的评估上海市皮肤病医院性病(sexually transmitted diseases,STD)诊疗中心女性就诊者中生殖支原体(MG)感染的患病率及相关因素,以期为指导临床增加或扩大MG检测提供依据。方法对2021年7—9月在上海市皮肤病医院STD门诊女性就诊者进行横断面研究。分别收集患者的宫颈拭子、咽拭子及直肠拭子。所有参与者填写匿名问卷。采用单因素和多因素logistic分析评估MG感染的相关因素。结果共收集到119份女性患者的有效问卷。排除2周内使用过抗生素的患者,共有98份宫颈拭子及咽拭子、88份直肠拭子纳入研究。入组患者上述3个部位的MG感染整体患病率为19.4%(19/98),其中在直肠拭子中最高(13.6%,12/88),其次是宫颈拭子(9.2%,9/98),咽拭子中最低(4.1%,4/98),三者之间差异无统计学意义(χ^(2)=5.300,P=0.071)。宫颈拭子MG感染患病率与患者高危性行为史显著相关(OR 22.933,95%CI 3.995~131.645,P<0.001)。三个解剖学部位MG感染与患者有无临床症状、是否合并其他STD无独立相关性。结论上海STD门诊女性就诊者中MG感染患病率较高,需引起广泛关注。其中有高危性活动史是患者生殖系统MG感染的危险因素。STD门诊中应积极开展MG筛查,为这些患者制定适当的治疗策略,以减少高危性活动人群中MG感染的传播。
Objective To investigate the prevalence of and risk factors for Mycoplasma genitalium infection among females visiting Sexually Transmitted Disease (STD) clinic of Shanghai Skin Disease Hospital for expanding laboratory testing of M.genitalium in clinical practice.Methods A cross-sectional study was conducted among STD clinic female attendees at Shanghai Skin Disease Hospital from July to September 2021.Cervical swabs,throat swabs,and rectal swabs were collected separately.All participants responded to an anonymous questionnaire with questions about socio-demographic status,sexual behavior,previous history of STD,and clinical symptoms and signs.Univariate and multivariate logistic analyses were used to analyze the risk factors associated with M.genitalium infection.Results A total of 119 valid questionnaires were collected from female patients.The females who had received antibiotics within 2 weeks were excluded.Finally,98 cervical swabs and throat swabs,and 88 rectal swabs were included in this study.The overall prevalence of M.genitalium in these three anatomical sites was 19.4% (19/98).The highest prevalence was in rectal swabs (13.6%,12/88),followed by cervical swabs (9.2%,9/98),and the lowest in throat swabs (4.1%,4/98).No significant difference was found between the three sets of samples in terms of M.genitalium prevalence (χ^(2)=5.300,P=0.071).M.genitalium positive cervical swab was significantly associated with high-risk sexual behavior in the last 6 months among female patients (OR 22.933,95% CI 3.995-131.645,P < 0.001).Only one (8.3%,1/12) of the M.genitalium positive rectal swab had a history of anal intercourse.There was no independent correlation between M.genitalium infection and clinical symptoms or co-infection with other STD at the three anatomical sites.Conclusions The high prevalence of M.genitalium among female patients at STD clinic of Shanghai Skin Disease Hospital is an issue of concern.Prior high-risk sexual behavior is a risk factor for M.genitalium infection in the reproductive system of women.M.genitalium screening test should be actively carried out at STD clinics.Appropriate treatment strategies should be developed for these patients to reduce the transmission of M.genitalium among populations with high-risk sexual behavior.
作者
闫静敏
姜南雁
叶美萍
王贵璇
冯鑫
尚梦雅
顾昕
石梅
倪立燕
龚伟明
成媛媛
朱琳
吴娟
周平玉
YAN Jingmin;JIANG Nanyan;YE Meiping;WANG Guixuan;FENG Xin;SHANG Mengya;GU Xin;SHI Mei;NI Liyan;GONG Weiming;CHENG Yuanyuan;ZHU Lin;WU Juan;ZHOU Pingyu(Shanghai Skin Disease Clinical College of Anhui Medical University,Shanghai Skin Disease Hospital,Shanghai 200050,China)
出处
《中国感染与化疗杂志》
CAS
CSCD
北大核心
2022年第5期570-576,共7页
Chinese Journal of Infection and Chemotherapy
基金
上海市科委(YDZX20193100002868,17DZ2293300)。
关键词
生殖支原体
性传播性疾病
女性
高危性行为
危险因素
Mycoplasma genitalium
sexually transmitted disease
female
high-risk sexual behavior
risk factor
