摘要
脑卒中是一种常见的脑血管疾病,具有高发病率、高致死率、高致残率的特点。神经细胞是组成中枢神经系统的基本单位,卒中发病时神经细胞会出现不同程度的损伤或细胞死亡现象。卒中后的神经细胞损伤也是导致患者神经功能障碍、影响其预后与生存质量的关键原因。因此,减轻卒中后的神经细胞损伤程度,延缓其细胞死亡进程有利于降低卒中幸存者的神经功能损伤水平,改善其预后效果,进而降低卒中致死、致残率。铁死亡是近年来被广泛关注的新型细胞死亡形式,已有研究证实卒中后的神经细胞存在铁死亡现象。作为一种可调节的细胞死亡形式,干预铁死亡可以实现对神经细胞损伤程度与死亡进程的调节。已有研究表明抑制铁死亡可以起到神经保护性作用。中医药具有多途径、多靶点的治疗优势,已被广泛应用于卒中的全疾病链条,并取得了较好的临床效果。以中医药调节铁死亡作为切入点可能是未来卒中治疗的新方向。该文简要阐述铁死亡机制,探讨中医药干预神经细胞铁死亡的研究现状,为进一步提升卒中的中医疗效提供参考。
Stroke is a common cerebrovascular disease,characterized by high incidence,mortality and disability rate.Neuronal cells,the basic unit of the central nervous system,can be injured to varying degrees when stroke occurs.Neuronal cell injury after stroke is also the key cause leading to neurological dysfunction,affecting the prognosis and quality of life of patients.Therefore,reducing the neuronal cell injury and delaying the process of cell death are effective to decrease the nerve function injury in stroke patients and improve their prognosis,thus lowering the death and disability rate of stroke.Ferroptosis is a new form of cell death that has been widely concerned in recent years.Several studies have confirmed that there is ferroptosis in neuronal cells after stroke.Since ferroptosis is an adjustable form,its intervention can help regulate the injury and death of neuronal cells.Studies have shown that inhibiting ferroptosis plays a role in protecting neuronal cells.Traditional Chinese medicine(TCM),with the multi-channel and multi-target treatment advantages,has been widely used in the whole stroke and has achieved good clinical efficacy.It might be a new direction taking TCM regulation of ferroptosis as the entry point for stroke treatment in the future.This review revealed the mechanism of ferroptosis,discussed the research status of TCM in intervening in neuronal cell ferroptosis,and provided reference for further improving the efficacy of TCM in stroke.
作者
徐寒莹
张艺缤
张冬梅
卢靖
张影
吴雷
兰天野
王健
XU Hanying;ZHANG Yibin;ZHANG Dongmei;LU Jing;ZHANG Ying;WU Lei;LAN Tianye;WANG Jian(Changchun University of Chinese Medicine,Changchun 130117,China;Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第20期232-240,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(82474317)
国家重点研发计划项目(2019YFC1709902)
国家中医药管理局项目(2019XZZXNB005)
吉林省科技发展计划项目(20210303004SF)
吉林省自然科学基金项目(20200201542JC)。
关键词
铁死亡
脑卒中
中医药
脑出血
脑梗死
Ferroptosis
stroke
traditional Chinese medicine
intracerebral hemorrhage
ischemic stroke
