摘要
目的比较不同剂量米非司酮联合腹腔镜手术治疗子宫内膜异位症(EMT)患者的临床效果。方法76例EMT患者,根据腹腔镜手术后米非司酮用药剂量的不同分为小剂量组与大剂量组,每组38例。小剂量组采用小剂量米非司酮联合腹腔镜手术治疗,大剂量组采用大剂量米非司酮联合腹腔镜手术治疗。比较两组治疗效果、复发率、不良反应发生率及治疗前后疼痛程度、血清促黄体生成素(LH)、雌二醇(E_(2))、泌乳素(PRL)、孕酮(P)、促卵泡生成素(FSH)水平。结果大剂量组患者治疗总有效率89.47%高于小剂量组的68.42%,差异有统计学意义(P<0.05)。大剂量组患者复发率5.26%低于小剂量组的23.68%,差异有统计学意义(P<0.05)。治疗前,两组患者数字疼痛评分法(NRS)评分比较差异无统计学意义(P>0.05);治疗后,两组NRS评分均低于本组治疗前,且大剂量组NRS评分(3.46±0.54)分低于小剂量组的(4.23±0.69)分,差异有统计学意义(P<0.05)。治疗前,两组患者LH、E_(2)、PRL、P、FSH比较,差异无统计学意义(P>0.05);治疗后,两组LH、E_(2)、PRL、P、FSH均低于本组治疗前,且大剂量组LH、E_(2)、PRL、P、FSH分别为(4.41±0.83)IU/L、(312.06±52.14)pmol/L、(280.14±39.33)μg/L、(16.22±2.75)nmol/L、(2.27±0.91)IU/L,均低于小剂量组的(5.53±0.97)IU/L、(371.23±64.08)pmol/L、(327.43±40.27)μg/L、(20.07±3.31)nmol/L、(3.42±1.03)IU/L,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论大剂量米非司酮联合腹腔镜手术治疗EMT的效果优于小剂量米非司酮联合腹腔镜手术,可明显降低复发率、疼痛程度和激素水平,且不会增加不良反应发生率。
Objective To compare the clinical effect of different doses of mifepristone combined with laparoscopic surgery in the treatment of patients with endometriosis(EMT).Methods A total of 76 cases of EMT patients were divided into low-dose group and high-dose group according to the different dosage of mifepristone after laparoscopic surgery,with 38 cases in each group.The low-dose group was treated with lowdose mifepristone combined with laparoscopic surgery,and the high-dose group was treated with high-dose mifepristone combined with laparoscopic surgery.Both groups were compared in terms of therapeutic effect,recurrence rate,incidence of adverse reactions,pain degree,serum luteinizing hormone(LH),estradiol(E_(2)),prolactin(PRL),progesterone(P),and follicle-stimulating hormone(FSH)level before and after treatment.Results The total effective rate 89.47%in the high-dose group was higher than 68.42%in the low-dose group,and the difference was statistically significant(P<0.05).The recurrence rate 5.26%in the high-dose group was lower than 23.68%in the low-dose group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in numerical rating scale(NRS)score between the two groups(P>0.05).After treatment,the NRS scores of the two groups were lower than those of this group before treatment,and the NRS score(3.46±0.54)points of the high-dose group was lower than(4.23±0.69)points of the low-dose group,and the differences were all statistically significant(P<0.05).Before treatment,there was no statistically significant difference in LH,E_(2),PRL,P,and FSH between the two groups(P>0.05).After treatment,the LH,E_(2),PRL,P,and FSH of the two groups were lower than those of this group before treatment,and the LH,E_(2),PRL,P,and FSH of the high-dose group were(4.41±0.83)IU/L,(312.06±52.14)pmol/L,(280.14±39.33)µg/L,(16.22±2.75)nmol/L,and(2.27±0.91)IU/L,which were lower than(5.53±0.97)IU/L,(371.23±64.08)pmol/L,(327.43±40.27)µg/L,(20.07±3.31)nmol/L,and(3.42±1.03)IU/L in the low-dose group,and the differences were all statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The efficacy of high-dose mifepristone combined with laparoscopic surgery in the treatment of EMT is superior to that of low-dose mifepristone combined with laparoscopic surgery,which can significantly reduce the recurrence rate,the pain degree and hormone levels without increasing the incidence of adverse reactions.
作者
洪惠兰
HONG Hui-lan(Department of Obstetrics and Gynecology,Ezhou Second Hospital,Ezhou 436000,China)
出处
《中国现代药物应用》
2022年第18期6-9,共4页
Chinese Journal of Modern Drug Application
