摘要
目的探讨2型糖尿病(T2DM)孕妇血清C反应蛋白(CRP)、可溶性细胞间黏附分子-1(sICAM-1)、25羟维生素D[25-(OH)D]水平变化与子痫前期(PE)发病的关系及对妊娠结局的预测价值。方法选取2018年1月至2020年12月海南省人民医院收治的148例T2DM孕妇作为研究对象,根据是否发生PE分为无PE组(129例)和PE组(19例)。比较两组孕妇一般资料及血清CRP、sICAM-1、25-(OH)D水平,分析上述生化指标与PE的关系及对妊娠结局的预测价值。结果两组孕妇前次妊娠PE病史、吸烟史、CRP、sICAM-1、25-(OH)D、胎盘生长因子(PLGF)、平均动脉压(MAP)水平比较,差异均有统计学意义(P<0.05);多因素Logistic回归分析结果显示,校正前次妊娠PE病史、吸烟史混杂因素后,CRP、sICAM-1、25-(OH)D、PLGF、MAP仍与PE的发生有关(P<0.05);不同妊娠结局孕妇血清CRP、sICAM-1、25-(OH)D水平比较,差异均有统计学意义(P<0.05);CRP、sICAM-1、25-(OH)D联合检测预测不良妊娠结局的受试者工作特征曲线下面积[0.899(95%CI:0.839~0.943)]最大。结论血清CRP、sICAM-1、25-(OH)D水平异常变化与T2DM孕妇并发PE有关,孕期检测3项血清指标水平对评估PE发生的风险及预测妊娠结局有重要价值。
Objective To explore the relationship between serum C-reactive protein(CRP),soluble intercellular adhesion molecule-1(sICAM-1),25-hydroxyvitamin D[25-(OH)D]levels and preeclampsia(PE)disease in pregnant women with type 2 diabetes mellitus(T2DM)and the predictive value for pregnancy outcome.Methods A total of 148 pregnant women with T2DM in Hainan Provincial People′s Hospital from January 2018 to December 2020 were selected as research objects.According to whether PE occurred,they were divided into non-PE group(129 cases)and PE group(19 cases).The general data,serum CRP,sICAM-1 and 25-(OH)D levels were compared between the two groups,and the relationship between the above-mentioned biochemical indicators and PE and the predictive value on pregnancy outcome were analyzed.Results The differences of previous pregnancy history of PE,smoking history,CRP,sICAM-1,25-(OH)D,placental growth factor(PLGF),and mean arterial pressure(MAP)levels between the two groups were statistically significant(P<0.05).Multivariate Logistic regression analysis results showed that after adjusting for the confounding factors of previous pregnancy history of PE and smoking history,CRP,sICAM-1,25-(OH)D,PLGF,and MAP were still related to the occurrence of PE(P<0.05).The differences of serum CRP,sICAM-1 and 25-(OH)D levels in pregnant women with different pregnancy outcomes were statistically significant(P<0.05).The area under the receiver operator characteristic curve of the combined detection of CRP,sICAM-1,and 25-(OH)D for predicting adverse pregnancy outcome was the largest,which was 0.899(95%CI:0.839-0.943).Conclusion The abnormal changes of serum CRP,sICAM-1,25-(OH)D levels are related to T2DM pregnant women with PE.The detection of three serum indicators during pregnancy has important value in assessing the risk of PE and predicting the pregnancy outcome.
作者
马乙云
李罡
MA Yiyun;LI Gang(Department of Clinical Laboratory,Hainan Provincial People′s Hospital/Hainan Hospital Affiliated to Hainan Medical College,Haikou,Hainan 570311,China;Department of Obstetrics,Hainan Provincial People′s Hospital/Hainan Hospital Affiliated to Hainan Medical College,Haikou,Hainan 570311,China)
出处
《国际检验医学杂志》
CAS
2022年第20期2441-2445,共5页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(81760275)
海南省卫生计生行业科研项目(18A200029)。
关键词
2型糖尿病
孕妇
C反应蛋白
可溶性细胞间黏附分子-1
子痫前期
type 2 diabetes mellitus
pregnant women
C-reactive protein
soluble intercellular adhesion molecule-1
preeclampsia
