摘要
目的比较靶区体积、计算网格和剂量阈值等参数对ArcCHECK、SRS MapCHECK和3DMap 3种验证设备的立体定向放射治疗剂量验证结果的影响。方法选取50例立体定向放疗计划,分别比较靶区体积(<25 cm^(3)和≥25 cm^(3))、计算网格(1.0、1.5和2.0 mm)和剂量阈值(5%、10%和15%)对3种验证设备3 mm/3%、3 mm/2%、3 mm/1%、2 mm/3%和2 mm/2%的γ通过率的影响。结果靶区体积的改变对于3DMap的影响较大,与小体积相比,3DMap大体积的3 mm/3%、3 mm/2%、2 mm/3%和2 mm/2%的γ通过率分别增加2.2%、2.2%、4.4%和4.7%(t=-2.76、-2.17、-4.72、-3.86,P<0.05);计算网格1.5和1.0 mm相比,对于MapCHECK的影响较大,5种γ通过率分别降低0.7%、1.1%、1.7%、0.9%和1.5%(t=-6.15、-6.23、-5.98、-5.11、-8.34,P<0.05)。计算网格2.0和1.0 mm相比,对于ArcCHECK影响较大,5种γ通过率分别降低1.0%、1.7%、2.4%、1.7%和2.7%(t=-4.75、-7.30、-8.63、-7.11、-8.26,P<0.05);剂量阈值10%和5%相比,对于ArcCHECK影响较大,3 mm/3%、3 mm/2%、2 mm/3%和2 mm/2%的γ通过率分别降低0.5%、0.8%、1.2%和1.7%(t=5.20、5.68、8.17、9.99,P<0.05)。剂量阈值15%和5%相比,对于3DMap的影响较大,3 mm/3%、3 mm/2%、2 mm/3%和2 mm/2%的γ通过率分别降低1.6%、1.7%、2.8%和3.2%(t=3.25、2.98、4.40、4.21,P<0.05)。结论靶区体积、计算网格和剂量阈值对3种验证设备立体定向放疗计划的验证通过率产生不同程度的影响。在临床使用时应对于不同的验证设备具体考虑这些参数对于验证结果的影响。
Objective To compare the effects of parameters,such as planning target volume(PTV),calculation grid size,and dose threshold,on the dosimetric verification result of three dosimetric verification systems ArcCHECK,SRS MapCHECK,and 3DMap for stereotactic body radiation therapy(SBRT).Methods Based on the dosimetric verification result of the SBRT plans of 50 patients,this study compared the effects of PTV(<25 cm^(3)and≥25 cm^(3)),calculation grid size(1.0,1.5,and 2.0 mm),and dose threshold(5%,10%,and 15%)on theγpassing rates of the three dosimetric verification systems at five criteria,i.e.,3 mm/3%,3 mm/2%,3 mm/1%,2 mm/3%,and 2 mm/2%.Results The changes in PTV affected 3DMap more significantly.With an increase in PTV,theγpassing rates of 3DMap at the criteria of 3 mm/3%,3 mm/2%,2 mm/3%,and 2 mm/2%increased by 2.2%,2.2%,4.4%,and 4.7%(t=-2.76,-2.17,-4.72,-3.86,P<0.05),respectively.The increase in the calculation grid from 1.0 mm to 1.5 mm had greater effect on MapCHECK,with theγpassing rates at the criteria of 3 mm/3%,3 mm/2%,3 mm/1%,2 mm/3%and 2 mm/2%decreased by 0.7%,1.1%,1.7%,0.9%,1.5%(t=-6.15,-6.23,-5.98,-5.11,-8.34,P<0.05),respectively.The increases in the calculation grid from 1.0 mm to 2.0 mm had greater impact on ArcCHECK,with theγpassing rates at the criteria of 3 mm/3%,3 mm/2%,3 mm/1%,2 mm/3%,2 mm/2%decreased by 1.0%,1.7%,2.4%,1.7%,2.7%(t=-4.75,-7.3,-8.63,-7.11,-8.26,P<0.05),respectively.The increase in the dose threshold from 5%to 10%had greater impact on ArcCHECK,with theγpassing rates at the criteria of 3 mm/3%,3 mm/2%,2 mm/3%and 2 mm/2%decreased by 1.1%,1.4%,2.5%,and 3.0%(t=5.20,5.68,8.17,9.99,P<0.05),respectively.Moreover,the increase in the dose threshold from 5%to 15%had more impact on 3DMap,with theγpassing rates at the criteria of 3 mm/3%,3 mm/2%,2 mm/3%,and 2 mm/2%decreased by 1.6%,1.7%,2.8%,and 3.2%(t=3.25,2.98,4.40,4.21,P<0.05),respectively.Conclusions Target volume,calculation grid,and dose threshold are influencing factors in the dosimetric verification of three dosimetric verification systems for SBRT.Therefore,the effects of these parameters should be considered for different verification systems in clinical applications.
作者
吴凡
唐斌
杨凤
吴骏翔
Wu Fan;Tang Bin;Yang Feng;Wu Junxiang(Radiation Oncology Key Laboratory of Sichuan Province,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,China)
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2022年第9期678-684,共7页
Chinese Journal of Radiological Medicine and Protection
基金
四川省重点研发项目(2021YFG0168,2021YFG0320,2022YFS0047)
肿瘤医工创新基金(ZYGX2021YGCX002)。
关键词
立体定向放射治疗
剂量验证
靶区体积
计算网格
剂量阈值
Stereotactic body radiation therapy
Dosimetric verification
Target volume
Calculation grid size
Dose threshold
