摘要
幽门螺杆菌(H.pylori)是一种定植在胃黏膜上皮的革兰阴性螺旋杆菌,可以诱发多种消化系统疾病,全球有一半以上的人感染H.pylori。在人体复杂而庞大的胃肠道微生态系统中,H.pylori可通过影响胃内环境来降低胃肠道菌群丰富度及多样性。胃肠道菌群与H.pylori共同作用,影响消化性溃疡、胃癌及缺铁性贫血等一系列消化系统疾病的发生发展,但其具体致病机制尚不明确。根除H.pylori可以提高胃肠道菌群的多样性,有助于预防H.pylori相关疾病的代际传播和进一步发展。H.pylori治疗期间补充益生菌可提高根除率,减少抗生素相关不良反应的发生。本文就H.pylori与胃肠道菌群关系的研究进展作一综述,以期探讨H.pylori的致病机制。
Helicobacter pylori(H.pylori) is a Gram-negative spiral bacterium colonized in gastric mucosal epithelium, which can induce a variety of digestive system diseases. More than half of the population in the world are infected with H.pylori. In the complex and huge gastrointestinal microecosystem of human body, H.pylori can reduce the richness and diversity of gastrointestinal flora by affecting the gastric environment. The joint effect of gastrointestinal flora and H.pylori has an impact on the occurrence and development of a series of internal and external gastrointestinal diseases such as peptic ulcer, gastric cancer and iron deficiency anemia, but the specific pathogenic mechanism is still unclear. Eradication of H.pylori can improve the diversity of gastrointestinal flora and help preventing intergenerational transmission and further development of H.pylori-related diseases. Probiotics supplementation during H.pylori treatment can improve the eradication rate and reduce the incidence of antibiotic related adverse reactions. In order to explore the pathogenic mechanism of H.pylori, this review provides a concise overview on the progress in research on the relationship between H.pylori and gastric flora.
作者
高珂
胡新俊
杨景云
王金梁
GAO Ke;HU Xin-jun;YANG Jing-yun;WANG Jin-liang(College of Clinical Medicine of He'nan University of Science and Technology,Luoyang,He'nan 471003,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2022年第8期963-968,973,共7页
Chinese Journal of Microecology
基金
国家自然科学基金(86100512)。
关键词
幽门螺杆菌
胃肠道菌群
微生态
Helicobacter pylori
Gastrointestinal flora
Microecology
