摘要
目的:观察布地奈德福莫特罗雾化吸入治疗老年慢性阻塞性肺疾病(COPD)合并支气管哮喘患者的效果。方法:选取2018年12月至2021年1月该院收治的76例老年COPD合并支气管哮喘患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各38例。对照组采用布地奈德雾化吸入治疗,观察组采用布地奈德福莫特罗雾化吸入治疗,比较两组临床疗效,治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、一秒率(FEV_(1)/FVC)]水平、炎性因子[白细胞介素(IL)-6、IL-8]水平及不良反应发生率。结果:观察组治疗总有效率为97.37%,高于对照组的78.95%,差异有统计学意义(P<0.05);治疗后,观察组FEV_(1)、FEV_(1)/FVC水平均高于对照组,差异有统计学意义(P<0.05);观察组IL-6、IL-8水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:布地奈德福莫特罗雾化吸入治疗老年COPD合并支气管哮喘患者,可提高临床疗效和肺功能指标水平,减轻机体炎症反应,其效果优于布地奈德雾化吸入治疗。
Objective:To observe effects of Budesonide/Formoterol aerosol inhalation in treatment of elderly patients with chronic obstructive pulmonary disease(COPD)and bronchial asthma.Methods:76 elderly patients with COPD and bronchial asthma who were admitted to this hospital from December 2018 to January 2021 were selected for the prospective study.They were divided into control group and observation group according to the random number table method,38 cases in each group.The control group received Budesonide aerosol inhalation therapy,while the observation group received Budesonide/Formoterol aerosol inhalation.The clinical efficacy,the levels of pulmonary function indexes[forced expiratory volume in 1 second(FEV_(1)),one-second rate(FEV_(1)/FVC)],the inflammatory factor levels[interleukin(IL)-6,IL-8],and incidence of adverse reactions were compared between the two groups before and after treatment.Results:The total effective rate of the observation group was 97.37%,which was higher than 78.95%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV_(1) and FEV_(1)/FVC in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of IL-6 and IL-8 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Budesonide/Formoterol aerosol inhalation in the treatment of the elderly patients with COPD and bronchial asthma can improve the clinical efficacy and the pulmonary function levels,and reduce the body’s inflammatory response.Moreover,it is superior to Budesonide aerosol inhalation therapy.
作者
王琼
WANG Qiong(Department of Infectious Diseases of Second Affiliated Hospital of Shenyang Medical College,Shenyang 110000 Liaoning,China)
出处
《中国民康医学》
2022年第18期57-60,共4页
Medical Journal of Chinese People’s Health
关键词
老年
慢性阻塞性肺疾病
支气管哮喘
布地奈德
福莫特罗
雾化
肺功能
炎性因子
Elderly
Chronic obstructive pulmonary disease
Bronchial asthma
Budesonide/Formoterol
Aerosol
Pulmonary function
Inflammatory factor
