摘要
目的:探讨慢性乙型肝炎患者乙肝病毒脱氧核糖核酸(HBV-DNA)载量与免疫球蛋白(Ig)、类风湿因子(RF)和超敏C反应蛋白(hs-CRP)水平的相关性。方法:回顾性分析2016年12月至2020年12月该院收治的60例慢性乙型肝炎患者的临床资料,使用实时荧光定量聚合酶链式反应(PCR)技术检测血清HBV-DNA载量,并根据其载量水平分为高载量组22例、中载量组18例和低载量组20例,比较三组Ig、RF和hs-CRP水平,分析HBV-DNA载量与IgG、IgA、IgM、RF、hs-CRP水平的相关性。结果:随着HBVDNA载量的增加,IgG、IgA、IgM水平逐渐升高,且高载量组>中载量组>低载量组,差异均有统计学意义(P<0.05);随着HBV-DNA载量的增加,hs-CRP、RF水平逐渐升高,且高载量组>中载量组>低载量组,差异均有统计学意义(P<0.05);经Pearson相关性分析显示,HBV-DNA载量与IgG、IgA、IgM、RF、hs-CRP水平均呈正相关(r>0,P<0.05)。结论:慢性乙型肝炎患者HBV-DNA载量与IgG、IgA、IgM、RF、hs-CRP水平均呈正相关,临床应加强对这些指标的监测,为制订个性化治疗方案提供指导。
Objective:To explore correlations among hepatitis B virus deoxyribonucleic acid(HBV-DNA)load and levels of immunoglobulin,rheumatoid factor(RF)and high-sensitivity C-reactive protein(hs-CRP)in patients with chronic hepatitis B.Methods:The clinical data of 60 patients with chronic hepatitis B admitted to this hospital from December 2016 to December 2020 were retrospectively analyzed.The serum HBV-DNA load was detected using real-time quantitative polymerase chain reaction(PCR)technology.According to the load levels,they were divided into high load group(22 cases),medium load group(18 cases),and low load group(20 cases).The levels of immunoglobulin,RF and hs-CRP were compared among the three groups.The correlations among the HBV-DNA load and the IgG,IgA,IgM,RF,hs-CRP levels were analyzed.Results:With the increase of HBV-DNA load,the levels of IgG,IgA and IgM gradually increased,the highload group>the medium-load group>the low-load group,the differences were statistically significant(P<0.05).With the increase of HBV-DNA load,the levels of hs-CRP and RF gradually increased,the high load group>the medium load group>the low load group,the differences were statistically significant(P<0.05).The Pearson correlation analysis showed that the HBV-DNA load was positively correlated with the levels of IgG,IgA,IgM,RF and hs-CRP(r>0,P<0.05).Conclusions:The HBV-DNA load in the patients with chronic hepatitis B is positively correlated with the levels of immunoglobulin,RF and hs-CRP.Therefore,the clinical monitoring of these indicators should be strengthened to guide to formulate the personalized treatment plans.
作者
吴丹
WU Dan(Department of Clinical Laboratory of Dongguan Hospital of Traditional Chinese Medicine,Dongguan 523000 Guangdong,China)
出处
《中国民康医学》
2022年第18期148-150,共3页
Medical Journal of Chinese People’s Health
