摘要
目的分析不同类型菌血症患者血清降钙素原(PCT)、C-反应蛋白(CRP)及白细胞介素-6(IL-6)的检出结果及意义。方法选择我院50例菌血症患者。统计记录PCT、CRP、IL-6分别在菌血症患者中的阳性检出率;分析革兰氏阳性菌、革兰氏阴性菌感染患者的PCT、CRP、IL-6检出结果;比较一般耐药、多重耐药及广泛耐药患者的PCT、CRP、IL-6检出结果。结果IL-6在菌血症患者中的阳性检出率高于PCT和CRP的阳性检出率(P<0.05)。50例菌血症患者共检出革兰氏阳性菌感染31例,革兰氏阴性菌感染19例。革兰氏阴性菌感染患者的PCT、CRP、IL-6水平显著高于革兰氏阳性菌感染患者(P<0.05)。革兰氏阳性菌感染患者的IL-6阳性检出率高于CRP阳性检出率(P<0.05)。50例菌血症患者中,检出一般耐药11例,多重耐药25例,广泛耐药14例。三种不同耐药程度患者的IL-6水平存在显著差异(P<0.05)。广泛耐药患者的IL-6水平高于多重耐药、一般耐药患者(P<0.05)。一般耐药患者的IL-6阳性检出率高于PCT及CRP阳性检出率(P<0.05)。结论血清PCT、CRP、IL-6在菌血症患者中的阳性检出率均较高,在不同菌种感染判断中,三者均有一定的价值,而在不同耐药程度判断方面IL-6的价值更高,因此在临床血液细菌培养前,可考虑综合三者进行菌血症的感染菌种、耐药程度判断。
Objective To analyze the detection results and significance of serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)in patients with different types of bacteremia.Methods A total of 50 patients with bacteremia admitted in our hospital were selected.The positive detection rates of PCT,CRP and IL-6 in patients with bacteremia were statistically recorded;the detection results of PCT,CRP and IL-6 in patients with Gram-positive bacterial infections and Gram-negative bacterial infections were analyzed;the detection results of PCT,CRP and IL-6 in patients with general drug resistance,multiple drug resistance and extensive drug resistance were compared.Results The positive detection rate of IL-6 in patients with bacteremia was higher than the positive detection rates of PCT and CRP(P<0.05).A total of 31 cases of Grampositive bacteria and 19 cases of Gram-negative bacteria were detected in 50 patients with bacteremia.The levels of PCT,CRP and IL-6 in patients with Gram-negative bacteria infections were significantly higher than those with Gram-positive bacteria infections(P<0.05).The positive detection rate of IL-6 in patients with Gram-positive bacterial infections was higher than the positive detection rate of CRP(P<0.05).Among 50 patients with bacteremia,11 cases of general drug resistance,25 cases of multidrug resistance and 14 cases of extensive drug resistance were detected.There was significant difference in IL-6level among patients with three different degrees of drug resistance(P<0.05).The level of IL-6 in patients with extensive drug resistance was higher than that in patients with multiple drug resistance and general drug resistance(P<0.05).The positive detection rate of IL-6 in patients with general drug resistance was higher than the postive detection rates of PCT and CRP(P<0.05).Conclusion The positive detection rates of serum PCT,CRP and IL-6 in patients with bacteremia were higher.In the judgment of different strains infections,the three has a certain value,and the value of IL-6 is higher in the judgment of different degrees of drug resistance.Therefore,the three can be considered to judge the infection strains and drug resistance of bacteremia before clinical blood bacterial culture.
作者
闫丹
杜小雨
YAN Dan;DU Xiaoyu(Clinical Laboratory Department,Henan Xinhe Hospital,Xinyang 465200;Clinical Laboratory Department,Women and Infants Hospital of Zhengzhou,Zhengzhou 450012,China)
出处
《临床医学研究与实践》
2022年第30期104-106,共3页
Clinical Research and Practice
