摘要
目的:探讨胃酸分泌抑制剂(奥美拉唑)的最佳给药时间。方法:选取本院2019年6月—2021年8月收治的80例胃酸患者作为研究对象,根据给药时间的不同分为A组和B组,每组40例。两组均给予奥美拉唑治疗,A组于早餐前30 min服用,B组于饭后1 h服用,比较两组治疗效果、胃内pH值及幽门螺杆菌清除率。结果:A组治疗总有效率为97.50%,高于B组的77.50%,差异有统计学意义(P<0.05);治疗后,两组胃内pH值高于治疗前,且A组高于B组,差异有统计学意义(P<0.05);A组清除率为87.50%,高于B组的62.50%,差异有统计学意义(P<0.05)。结论:奥美拉唑早餐前30 min服用治疗效果较为突出,且胃内pH值改善明显,幽门螺杆菌清除率更高。
Objective:To explore the optimal administration time of gastric acid secretion inhibitor(omeprazole).Methods:A total of 80 patients with gastric acid admitted to our hospital from June 2019 to August 2021 were selected and divided into group A and group B according to different administration time,with 40 cases in each group.Both groups were treated with omeprazole.Group A was taken 30 min before breakfast,and group B was taken 1 h after breakfast.The therapeutic effect,gastric pH value and Helicobacter pylori clearance rate were compared between the two groups.Result:The total effective rate of group A was 97.50%,which was higher than 77.50%of group B,and the difference was statistically significant(P<0.05).After treatment,the gastric pH value in the two groups was higher than that before treatment,and that in group A was higher than that in group B,the difference was statistically significant(P<0.05).The clearance rate of group A was 87.50%,which was higher than 62.50%of group B,and the difference was statistically significant(P<0.05).Conclusion:Omeprazole taken 30 minutes before breakfast has prominent therapeutic effect,which can significantly improves the pH value in the stomach,and has a higher clearance rate of Helicobacter pylori.
作者
徐侠
王树俊
吴凤霞
XU Xia;WANG Shujun;WU Fengxia(Department of Gastroenterology,Zhengzhou first people's Hospital,Zhengzhou,Henan 450000 China)
出处
《中国药物滥用防治杂志》
CAS
2022年第9期1250-1252,共3页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
奥美拉唑
胃酸分泌抑制剂
给药时间
消化性溃疡
Omeprazole
Gastric acid secretion inhibitor
Administration time
Peptic ulcer
