摘要
目的:探讨银杏酮酯滴丸联合冠心病二级预防对不稳定型心绞痛的临床疗效及斑块稳定性的影响。方法:选取鄂州市中心医院2020年9月-2022年3月门诊及病房收治不稳定型心绞痛患者120例,分为联合组及对照组,各60例。对照组给予冠心病二级预防治疗,联合组在对照组治疗基础上给予银杏酮酯滴丸4丸/次,3次/d口服治疗,两组患者均治疗6个月。对比两组患者临床疗效,观察两组患者治疗前后心绞痛症状积分、斑块稳定性变化;检测两组患者治疗前后血清hs-CRP、IL-6、CatK、Sirt1、MMP-2及MMP-9水平变化。结果:联合组治疗不稳定型心绞痛临床疗效优于对照组(P<0.05),两组总有效率无明显差异(P>0.05);与治疗前比较,两组患者心绞痛症状积分均降低,斑块稳定性升高,血清hsCRP、IL-6、CatK、Sirt1、MMP-2及MMP-9水平(P<0.05),且联合组上述指标改善程度均优于对照组(P<0.05)。结论:银杏酮酯滴丸联合冠心病二级预防可有效改善稳定型心绞痛患者临床症状,并提高斑块稳定性。
Objective: To investigate the effect of Ginkgo Biloba Extract Dripping Pill combined with secondary prevention of coronary heart disease on unstable angina pectoris and plaque stability. Methods: 120 patients with unstable angina pectoris in the outpatient and ward of the Ezhou Central Hospital of Dongying City from February 2018 to July 2019 were divided into the combination group and the control group, 60 cases in each group. The control group was given the secondary preventive treatment of coronary heart disease, and the combined group was given Ginkgo Biloba Extract Dripping Pill 4 capsules/time, 3 times/d on the basis of the control group treatment. Both groups were treated for 6 months. The clinical efficacy was compared between the two groups, and the changes of angina symptom score and plaque stability before and after treatment were observed;the changes of serum hs-CRP, IL-6, CatK, Sirt1, MMP-2 and MMP-9 were detected by ELISA. Results: The clinical efficacy of the combined group was better than that of the control group(P<0.05), and there was no significant difference in the total effective rate between the two groups(P>0.05);compared with before treatment, the angina symptom scores of the two groups were decreased, the plaque stability was increased, and the contents of hs-CRP, IL-6, CatK, Sirt1, MMP-2 and MMP-9 were decreased(P<0.05), and the improvement degree of the above indexes in the combined group was excellent compared with the control group(P<0.05).Conclusion: Ginkgo Biloba Extract Dripping Pill combined with secondary prevention of coronary heart disease can effectively improve the clinical symptoms of patients with stable angina pectoris and improve the stability of plaque.
作者
陈园
胡锦辉
Chen Yuan;Hu Jinhui(Health Center of Bishidu Town,Echeng District,Ezhou City,Hubei Province,Ezhou 436000;Ezhou Maternal and Child Health Hospital,Ezhou 436000)
出处
《数理医药学杂志》
CAS
2022年第11期1736-1740,共5页
Journal of Mathematical Medicine
关键词
银杏酮酯滴丸
冠心病二级预防
不稳定型心绞痛
斑块稳定性
Ginkgo Biloba Extract Dripping Pill
Secondary prevention of coronary heart disease
Unstable angina pectoris
Plaque stability
