摘要
目的探讨内脏脂肪组织丝氨酸蛋白酶抑制因子(visceral adipose tissue-derived serine protease inhibitor,Vaspin)、乙酰肝素酶(heparanase,HSPE)、高敏肌钙蛋白T(high-sensitivity troponin T,hs-cTnT)在急性冠状动脉综合征(acute coronary syndrome,ACS)患者中的表达情况及其对预后的影响。方法选择2019年1-12月在衡水市第五人民医院检验科诊断为ACS的206例患者,入院时检测患者的脂肪因子[脂联素(adiponectin,APN)、Vaspin]、HSPE、心肌损伤标志物[肌酸激酶(creatine kinase,CK)、肌酸激酶同工酶(creatine kinase isoenzymes,CK-MB)、乳酸脱氢酶(lactate dehydrogenase,LDH)、hs-cTnT],比较不同预后结局患者的脂肪因子、HSPE、心肌损伤标志物差异,以及入院时Vaspin、HPSE、hs-cTnT对ACS患者预后的影响以及预测价值。结果ACS患者发病后1年内,预后不良发生率为22.82%。预后不良患者Vaspin低于预后良好患者,HSPE、CK、CK-MB、LDH、hs-cTnT高于预后良好患者,差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,Vaspin高表达可能是ACS患者预后不良的保护因子(OR<1.00,P<0.05),HSPE、CK、CK-MB、LDH、hs-cTnT高表达可能是ACS患者预后不良的风险因子(OR>1.00,P<0.05)。ROC曲线显示,入院时血清Vaspin、HPSE、hs-cTnT水平单独及联合对ACS均有一定预测价值;ACS患者血清Vaspin与HPSE、hs-cTnT均呈负相关(r<0.00,P<0.05),HPSE与hs-cTnT呈正相关(r>0.00,P<0.05)。结论Vaspin、HPSE、hs-cTnT与ACS患者预后相关,可用于ACS患者预后的预测。
Objective To investigate the expression of visceral adipose tissue serine protease inhibitor(visceral adipose tissue-derived serine protease inhibitor,Vaspin),heparanase(heparanase,HSPE),high-sensitivity troponin T(high-sensitivity troponin T,hs-cTnT)in patients with acute coronary syndrome(acute coronary syndrome,ACS)and its impact on prognosis.Methods A total of 206 ACS patients in the laboratory of the hospital from January 2018 to November 2018 were selected as the research subjects,and the adipokines[adiponectin(adiponectin,APN),Vaspin],HSPE,and myocardial injury markers[creatine kinase(creatine kinase,CK),creatine kinase isoenzyme(creatine kinase isoenzymes,CK-MB),lactate dehydrogenase(lactate dehydrogenase,LDH),hs-cTnT],markers of myocardial injury,focusing on the impact of Vaspin,HPSE,hs-cTnT on the prognosis and predictive value of ACS patients at admission.Results Within 1 year after the onset of ACS,the incidence of poor prognosis was 22.82%.Vaspin in poor prognosis group was lower than that in good prognosis group,HSPE,CK,CK-MB,LDH,hs-cTnT were higher than that in good prognosis group,the difference was statistically significant(P<0.05).Logistic regression analysis showed that the high expression of Vaspin may be a protective factor for poor prognosis of the ACS patients(OR<1.00,P<0.05),and the high expression of HSPE,CK,CK-MB,LDH,hs-cTnT may be the risk factor for poor prognosis of the ACS patients(OR>1.00,P<0.05).The results of ROC curve showed that serum Vaspin,HPSE,hs-cTnT levels alone and in combination at admission had certain predictive value for ACS;Serum Vaspin in ACS patients was negatively correlated with HPSE and hs-cTnT(r<0.00,P<0.05),while HPSE was positively correlated with hs-cTnT(r>0.00,P<0.05).Conclusion Vaspin,HPSE and hs-cTnT are related to the prognosis of the ACS patients and can be used to predict the prognosis of ACS patients.
作者
刘海燕
刘兰凤
田斌
王晓荣
梁红
邓虎重
LIU Haiyan;LIU Lanfeng;TIAN Bin;WANG Xiaorong;LIANG Hong;DENG Huzhong(Department of Laboratory,the Fifth People's Hospital of Hengshui,Hengshui Hebei 053000,China)
出处
《新疆医科大学学报》
CAS
2022年第11期1290-1295,共6页
Journal of Xinjiang Medical University
基金
衡水市科技计划项目(2019014063Z)。
