摘要
目的比较丙泊酚与环泊酚分别复合羟考酮用于人流术的麻醉效果及不良反应。方法选择2022年2-3月我院自愿要求麻醉镇痛且终止妊娠的患者460例,ASA分级I~II级,随机分为A组(丙泊酚复合羟考酮)、B组(环泊酚复合羟考酮),每组230例。两组均经静脉缓慢注射0.04 mg/kg盐酸羟考酮注射液,然后分别给予2 mg/kg丙泊酚与0.4 mg/kg环泊酚注射液,观察两组患者用药后静脉注射痛、呼吸抑制及其他不良反应发生率,对比分析不同时点T0(注射药物前)、T1(睫毛反射消失时)、T2(宫腔操作时)、T3(结束唤醒时)的平均动脉压(MAP)、心率(HR)、氧饱和度(SpO_(2))、呼吸频率(RR)和脑电双频指数(BIS)及苏醒时、苏醒后30 min及苏醒后1 h的VAS评分,记录苏醒时间、定向力恢复时间和患者满意度。结果与A组比较,B组静脉注射痛和呼吸抑制显著降低(P<0.05)。与T0时点比较,A组T1、T2时点MAP、SpO_(2)降低,T1、T2、T3时点HR减慢,差异均有统计学意义(P<0.05);B组MAP在T1时点下降,差异有统计学意义(P<0.05),SpO_(2)、HR在各时点差异无统计学意义(P>0.05)。与A组比较,B组MAP、SpO_(2)在T1、T2时点升高,HR在T1~T3时点加快,且差异均有统计学意义(P<0.05)。各时点RR组间组内比较差异均无统计学意义(P>0.05)。各时点BIS组间比较差异无统计学意义(P>0.05)。苏醒时、苏醒后30 min及苏醒后1 h VAS评分差异无统计学意义(P>0.05)。与A组比较,B组苏醒时间差异无统计学意义(P>0.05),B组定向力恢复时间短、患者满意度高且差异均有统计学意义(P<0.05)。结论环泊酚复合羟考酮用于人流术,镇静镇痛效果确切,不良反应发生率明显低于丙泊酚复合羟考酮,患者循环呼吸更稳定,定向力恢复快且麻醉效果满意度高。
Objective To compare the anesthetic effect and adverse reactions of propofol with those of ciprofol respectively combined with oxycodone in abortion.Methods Totally 460 patients who voluntarily requested anesthesia and terminated pregnancy from February 2022 to March 2022 in our hospital were randomly divided into group A(propofol combined with oxycodone)and group B(ciprofol combined with oxycodone),with 230 cases in each group.Both groups were slowly injected with 0.04 mg/kg oxycodone hydrochloride injection,and then 2 mg/kg propofol and 0.4 mg/kg ciprofol injection respectively.The incidence of intravenous injection pain,respiratory depression and other adverse reactions were observed.The mean arterial pressure(MAP),heart rate(HR),oxygen saturation(SpO_(2)),respiratory rate(RR)and bispectral index(BIS)at T0(before drug injection),T1(when eyelash reflex disappeared),T2(at intrauterine operation)and T3(at awakening),and VAS scores at awakening,30 min after awakening and 1 h after awakening were compared and analyzed.The recovery time,orientation recovery time and patient satisfaction were recorded.Results Compared with group A,respiratory depression and intravenous injection pain in group B were significantly decreased(P<0.05).Compared with T0,MAP and SpO_(2) in group A at T1 and T2 decreased,while HR at T1,T2 and T3 decreased(P<0.05).Compared with T0,MAP in group B decreased at T1 with statistical difference(P<0.05),while SpO_(2) and HR showed no significant difference at each time point(P>0.05).Compared with group A,MAP and SpO_(2) in group B increased at T1 and T2,and HR in group B increased at T1~T3 with statistical difference(P<0.05).There was no significant difference in RR between the two groups at each time point(P>0.05).There was no significant difference in BIS between the two groups at each time point(P>0.05).There was no significant difference in VAS score between the two groups at awakening,30 min after awakening and 1 h after awakening(P>0.05).Compared with group A,the recovery time of orientation force in group B was shorter,and the patient′s satisfaction degree was higher with statistical difference(P<0.05),while there was no significant difference in the recovery time between the two groups(P>0.05).Conclusion Ciprofol combined with oxycodone has definite sedative and analgesic effects in abortion,and the incidence of adverse reactions is significantly lower than that of propofol combined with oxycodone.The patients are more stable in circulation and respiration with fast recovery time of orientation and good satisfaction in anesthesia.
作者
贾畅
曹惠鹃
孙莹杰
张晓东
李健
刁玉刚
张铁铮
Jia Chang;Cao Huijuan;Sun Yingjie;Zhang Xiaodong;Li Jian;Diao Yugang;Zhang Tiezheng(Department of Anesthesiology,General Hospital of Northern Theater Command,Shengyang 110016,China)
出处
《实用药物与临床》
CAS
2022年第11期1012-1015,共4页
Practical Pharmacy and Clinical Remedies
基金
辽宁省自然基金项目(2020-MS-041)。
