摘要
目的分析超声Finkler评分联合血清CA125、CA724用于卵巢肿瘤良恶性鉴别诊断中的应用价值。方法选取我院2018年1月-2021年12月收治的62例卵巢肿瘤患者作为研究对象,评估患者超声Finkler评分并检测血清CA125、CA724水平,分析三项指标在卵巢肿瘤良恶性鉴别诊断中的应用价值。结果病理检查显示,良性48例、恶性14例;恶性肿瘤患者超声Finkler评分、血清CA125以及CA724水平均高于良性肿瘤患者,差异有统计学意义(P<0.05);超声Finkler评分检测显示,良性45例、恶性17例;血清CA125检测显示,良性43例、恶性19例;血清CA724检测显示,良性47例、恶性15例;联合检测显示,良性48例,恶性14例;超声Finkler评分、血清CA125以及CA724诊断灵敏度、特异度以及准确率比较,差异无统计学意义(P>0.05);联合检测灵敏度、特异度、准确度高于任意单项检测,差异有统计学意义(P<0.05);超声Finkler评分的ROC曲线下面积为0.862(0.772~0.951);血清CA125的ROC曲线下面积为0.857(0.674~1.000);血清CA724的ROC曲线下面积为0.808(0.682~0.988);联合检测的ROC曲线下面积为0.893(0.754~1.000)。结论超声Finkler评分、血清CA125以及CA724在卵巢肿瘤良恶性鉴别诊断中均具有一定的应用价值,但单独检测存在一定的局限性,联合检测能够有效提高诊断准确率,避免误诊、漏诊等情况,值得临床应用。
Objective To analyze the application value of ultrasound Finkler score combined with serum CA125 and CA724 in the differential diagnosis of benign and malignant ovarian tumors.Methods A total of 62 patients with ovarian tumors admitted to our hospital from January 2018 to December 2021 were selected as the research objects.The ultrasound Finkler score was evaluated and the serum CA125 and CA724 levels were detected.The application value of the three indicators in the differential diagnosis of benign and malignant ovarian tumors was analyzed.Results Pathological examination showed that 48 cases were benign and 14 cases were malignant.The ultrasound Finkler score,serum CA125 and CA724 levels in patients with malignant tumors were higher than those in patients with benign tumors,and the differences were statistically significant(P<0.05).Ultrasound Finkler score showed 45 cases of benign and 17 cases of malignant.Serum CA125 detection showed 43 cases of benign and 19 cases of malignant.Serum CA724 detection showed 47 cases of benign and 15 cases of malignant.Combined detection showed 48 cases of benign and 14 cases of malignant;there was no significant difference in the diagnostic sensitivity,specificity and accuracy of ultrasound Finkler score,serum CA125 and CA724(P>0.05).The sensitivity,specificity and accuracy of combined detection were higher than those of any single detection,and the differences were statistically significant(P<0.05).The area under ROC curve of ultrasonic Finkler score was 0.862(0.772-0.951).The area under ROC curve of serum CA125 was 0.857(0.674-1.000).The area under ROC curve of serum CA724 was 0.808(0.682-0.988).The area under ROC curve of combined detection was 0.893(0.754-1.000).Conclusion Ultrasound Finkler score,serum CA125 and CA724 have certain application value in the differential diagnosis of benign and malignant ovarian tumors,but there are some limitations in single detection.Combined detection can effectively improve the diagnostic accuracy and avoid misdiagnosis and missed diagnosis,which is worthy of clinical application.
作者
刘海兵
汪洪雷
LIU Hai-bing;WANG Hong-lei(Department of Ultrasound,Hengfeng County Hospital of Traditional Chinese Medicine,Hengfeng 334300,Jiangxi,China;Department of Ultrasound,Shangrao Maternal and Child Health Hospital,Shangrao 334000,Jiangxi,China)
出处
《医学信息》
2022年第20期56-59,共4页
Journal of Medical Information
