摘要
目的研究新型冠状病毒肺炎患者的补体系统是否受新冠疫苗接种的影响,同时探讨补体与新冠肺炎患者住院时间的关系,为临床诊疗和新冠患者的管理提供借鉴。方法选取2021年11月1日—11月30日广州医科大学附属市八医院收治的新冠肺炎患者为研究对象,根据患者近半年内是否进行过疫苗接种,分为近半年无接种史组和近半年有接种史组,检测C3、C4、IgG、IgM、IgA、新冠病毒抗体IgG与IgM、中性粒细胞及淋巴细胞绝对值计数,记录所有患者的住院天数,再根据患者住院天数14 d作为界限,分为≤14 d组和>14 d组,比较两组上述免疫相关指标。结果近半年内有接种第一针疫苗的患者C3浓度为(0.86±0.157)g/L,第一针已超半年者为(0.96±0.172)g/L,近半年内有疫苗接种史的患者C3浓度更低(P<0.05),但C4、IgG、IgM、IgA、新冠病毒抗体IgG与IgM、中性粒细胞及淋巴细胞绝对值计数等指标,两组未见显著性差异;住院≤14 d的患者,C3和C4浓度均比住院>14 d的患者更低,但新冠病毒抗体IgG与IgM、淋巴细胞绝对值均更高(P均<0.05)。结论半年内启动的疫苗接种可使人体的免疫功能和补体系统更早期对病毒进行识别,更有利于清除病毒,但该效应在半年后减弱;结合入院时C3、C4、新冠抗体IgG水平与淋巴细胞绝对计数等指标可以综合预测新冠肺炎患者的住院时间。
Objective To investigate whether the complement system of COVID-19 is affected by vaccination,and also to explore the relationship between complement and length of stay in hospital,with a view to providing input for clinical diagnosis and the management of COVID-19 patients.Methods The patients admitted from November 1st to November 30th,2021 in the Eighth Affiliated Hospital of Guangzhou Medical University were selected as subjects.According to the time of vaccination,the patients were divided into two groups as vaccinated within half a year and over half a year.Then C3,C4,IgG,IgM,IgA,COVID-19 IgG and IgM,neutral granulocyte and lymphocyte count were detected and all patients'hospitalized days were recorded.With their hospitalization days of 14 d as a threshold,the patients were divided into two groups,and the above indicators were compared.Results C3 concentration was(0.86±0.157)g/L in patients with vaccination within six months,which is significantly lower than(0.96±0.172)g/L in those over six months(P<0.05),but as for C4,IgG,IgM,IgA,COVID-19 IgG and IgM,neutral granulocyte and lymphocyte counts,there were no significant difference between two groups;as for the patients within 14 days of hospitalization,C3 and C4 concentrations were lower than those for more than 14 days,but the COVID-19 antibody IgG and IgM,lymphocyte counts were higher(all P<0.05).Conclusion Vaccination within half a year can make the body's immune function and complement system to identify viruses earlier,more beneficial to remove viruses,but this effect is weakened after half a year;when admission,C3,C4,COVID-19 IgG level and lymphocyte counts can be used to predict hospitalization time in COVID-19 patients.
作者
陈沐
张德荣
韩俊彦
袁伟锋
CHEN Mu;ZHANG De-rong;HAN Jun-yan;YUAN Wei-feng(Department of Pneumology,the Eighth Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510060,China)
出处
《中国热带医学》
CAS
2022年第10期980-983,共4页
China Tropical Medicine
关键词
补体
新冠肺炎
疫苗
住院时间
Complement
COVID-19
vaccination
hospital stay
