摘要
急性脑梗死(ACI)又称缺血性脑卒中,是一种致残率极高的疾病,给社会和家庭带来了沉重的负担。其发病机制与诸多因素相关,其中炎症学说是重要的机制之一。急性脑梗死早期,小胶质细胞被激活,其释放的炎症介质[如白细胞介素类、肿瘤坏死因子-α(TNF-α)等]诱导血管内皮细胞表达黏附分子等,促使循环中的白细胞(中性粒细胞、单核-巨噬细胞等)滚动、黏附至损伤的血管内皮,迁移并穿过血脑屏障,渗透、浸润脑实质,通过释放多种促炎介质进一步扩大局部炎症反应,加剧损伤部位及缺血半暗带的组织损伤。中医认为中风的发生与各种原因导致的瘀血痹阻脑脉有关,治疗该病具有优势。该文综述了近年来活血治疗对急性脑梗死患者炎症因子影响研究进展,就其调节急性脑梗死炎症因子如白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、TNF-α、C反应蛋白(CRP)、单核细胞趋化蛋白-1(MCP-1)等进行论述,以期阐明中医药治疗急性脑梗死的科学内涵,并为进一步研究奠定基础。
Acute cerebral infarction(ACI),also known as ischemic stroke,is a disease with a high disability rate,which brings heavy burdens to society and families.Its pathogenesis is related to many factors,of which the inflammatory theory is one of the important mechanisms.In the early stage of ACI,microglia are activated,and the inflammatory mediators,such as interleukins and tumor necrosis factor-α(TNF-α),released by them induce vascular endothelial cells to express adhesion molecules.The circulating leukocytes(neutrophils,monocyte-macrophages,etc.) are promoted to roll and adhere to the injured vascular endothelium,migrate and cross the blood-brain barrier,penetrate and infiltrate the brain parenchyma,and further expand the local inflammatory response by releasing a variety of proinflammatory mediators,thus exacerbating the tissue injury at the injury site and ischemic penumbra.Traditional Chinese medicine(TCM)has advantages in treating the disease.TCM believes that the occurrence of stroke is related to blood stasis caused by various reasons,which block the brain vessel.This article reviewed the research progress on the effect of activating blood therapy on inflammatory factors in patients with ACI in recent years and discussed its regulation of inflammatory factors in ACI such as interleukin-1(IL-1),interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10),TNF-α,C reactive protein(CRP),and monocyte chemotactic protein-1(MCP-1),hoping to elucidate the scientific connotation of TCM treatment of ACI and lay the foundation for further research.
作者
张怡
张宏
高林
帅垠琦
刘小庆
蒋海南
张晓云
ZHANG Yi;ZHANG Hong;GAO Lin;SHUAI Yinqi;LIU Xiaoqing;JIANG Hainan;ZHANG Xiaoyun(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第23期250-263,共14页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(30973747)
国家中医药管理局应用基础研究项目(zyjc20161015)
四川省中医药管理局重大专项(2020ZD003)
四川省中医药管理局中医药基础项目(2021MS106)。
关键词
中医药
活血治疗
急性脑梗死
炎症因子
研究进展
traditional Chinese medicine
activating blood therapy
acute cerebral infarction
inflammatory factors
research progress
