摘要
癫痫,即中医所言“痫病”,是常见的神经系统疾病之一。中医认为癫痫发病常与引动肝风相关,多从肝论治,治法平肝息风,疏肝理气。临床上,常采用柴胡和天麻两种中药治疗癫痫。柴胡可通过多个通路改变细胞内离子浓度,通过调节突触前钙离子通路调控神经递质的分泌并显著提高ATP的含量,起到抗癫痫作用;天麻可保护海马区神经元,抑制海马区炎症,调控神经递质的分泌,有效改变癫痫的病理状态。本文对这两种中药相关的抗癫痫作用研究进行综述,以期为犬临床癫痫的治疗和相关药物的研发提供参考。
Epilepsy,or“Xian Disease”in Traditional Chinese Medicine,is one of the common neurological diseases.Traditional Chinese Medicine theory believes that the onset of epilepsy is often associated with the liver wind,so most of the time the liver treatment is elected which calms the liver wind and harmonize bodyand Qi.Bupleurum chinese DC.and Gastrodia elata Bl.are two kinds of traditional Chinese medicine commonly used in the treatment of epilepsy.The active ingredients of Bupleurum chinense DC have been suspected to conduct anti⁃epileptic effect by changing the intracellular ion concentration through multiple pathways,including regulating the secretion of neurotransmitters and significantly increasing the content of ATP by regulating the presynaptic calcium ion pathway.The active ingredients of Gastrodia elata Bl.can effectively change the pathological state of epilepsy by protecting neurons in the hippocampus,inhibiting inflammation in the hippocampus and regulating the secretion of neurotransmitters.In this paper,the antiepileptic effect of these two Traditional Chinese Medicine was reviewed to provide references for clinical treatment and drug development for canine epilepsy.
作者
宋世豪
李欣苒
万瑾怡
杨晓愉
林毓暐
林珈好
SONG Shihao;LI Xinran;WAN Jinyi;YANG Xiaoyu;LIN Yuwei;LIN Jiahao(College of veterinary medicine,China Agricultural University,Beijing 100193;College of Bioligical Science,China Agricultural University,Beijing 100193;Center of Research and Innovation of Traditional Chinese Veterinary Medicine,China Agricultural University,Beijing 100193;Shanghai Naughty Family Pets Co.,Shanghai,200335)
出处
《广东畜牧兽医科技》
2022年第6期87-92,共6页
Guangdong Journal of Animal and Veterinary Science
基金
中国农业大学2115人才工程(00109023)
卓越临床中兽医专项研究生国际影响力提升项目(JG202015)。
关键词
柴胡
天麻
中医药
癫痫
犬
Bupleurum chinense DC.
Gastrodia elata Bl.
Traditional Chinese medicine
Epilepsy
Dog
