摘要
目的探讨单次高剂量静脉注射人免疫球蛋白(IVIG)联合间歇性蓝光治疗新生儿ABO溶血病的疗效。方法以260例ABO溶血病患儿为对象,盲选法分为观察组[双面蓝光间断照射+单次高剂量IVIG;1.0 g/(kg·d)]与对照组[双面蓝光间断照射^(+)常规剂量IVIG;0.4 g/(kg·d)]。对比2组治疗效果。结果观察组黄疸消退、住院、蓝光照射时间低于对照组(P<0.05)。2组患儿总胆红素(TBiL)水平随观察时间延长均降低,观察组变化幅度高于对照组(P<0.05)。2组治疗后CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)升高,血红蛋白(Hb)水平降低,观察组CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)、Hb水平高于对照组(P<0.05)。观察组贫血、换血率分别为4.62%、1.54%,低于对照组的17.69%、12.31%,(P<0.05)。结论单次高剂量IVIG联合间歇蓝光治疗ABO新生儿溶血病,可快速控制患儿症状,促进TBiL排泄,减轻溶血反应,减少贫血、换血的发生。
Objective To explore single high-dose intravenous injection of immunoglobulin(IVIG)and intermittent blue to treat neonatal ABO hemolytic disease.Methods 260 cases of ABO hemolyver patients were used as objects.The blind selection was divided into observation group[double-sided blue intermittent irradiation+single high dose IVIG;1.0 g(/kg·d)]and control group[double-sided Blu-ray intermittently+conventional dose IVIG;0.4 g/(kg·d)].The two groups of treatment had been compared.Results Observing group jaundice,hospitalization,blue light irradiation time was lower than the control group(P<0.05).the TBIL level of the two groups was decreased with the prolonging of the observation time.Snd the observation group changed higher than the control group(P<0.05).Two groups of CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+)increased after treatment,the Hemoglobin(HB)level was lowered,and the observation group CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+),HB level was higher than the control group(P<0.05).Observation group anemia,blood transfer rate was 4.62%,1.54%,which was lower than the control group 17.69%,12.31%(P<0.05).Conclusion These early results indicate that single high dose IVIG and intermittent blue to treat ABO neonatal hemolysis,can quickly control symptoms of children,promote TBIL excretion,reduce hemolytic reaction,reduce anemia,blood transfusion.
作者
钱国胜
Qian Guosheng(The People's Hospital of Ningguo City,Ningguo,Anhui 242300)
出处
《基层医学论坛》
2022年第34期11-13,共3页
The Medical Forum
