摘要
目的探讨益肾逐瘀法治疗痰瘀互结型多囊卵巢综合征(PCOS)所致不孕症的效果,以及其对患者糖脂代谢、血清C1q肿瘤坏死因子相关蛋白9(CTRP9)水平的影响。方法选择94例痰瘀互结型PCOS所致不孕症患者,将其随机分为对照组和中药组,每组47例。对照组采用单纯西医治疗,中药组在西药治疗的基础上口服益肾逐瘀自拟方治疗。比较两组患者治疗前后体质指数、糖代谢指标[空腹血糖(FBG)、空腹胰岛素(Fins)、稳态模型评估胰岛素抵抗(HOMA-IR)指数]、脂代谢指标(血清总胆固醇、三酰甘油、HDL、LDL)、生殖内分泌指标[促卵泡激素(FSH)、黄体生成素(LH)、雌二醇]、血清CTRP9水平,以及治疗后的排卵率及妊娠率。结果治疗后,两组的体质指数、FBG水平、Fins水平、HOMA-IR指数、总胆固醇水平、三酰甘油水平、LDL水平、LH水平均低于治疗前,HDL、FSH、雌二醇、血清CTRP9水平均高于治疗前,且中药组的体质指数、FBG水平、Fins水平、HOMA-IR指数、三酰甘油水平、LDL水平、HDL水平、LH水平、FSH水平、血清CTRP9水平均优于对照组(均P<0.05)。中药组总妊娠率、总排卵率均高于对照组(均P<0.05)。结论在常规西医治疗的基础上应用益肾逐瘀自拟方能够更好地提高痰瘀互结型PCOS所致不孕症患者的排卵率和妊娠率,改善其糖脂代谢水平和血清CTRP9水平。
Objective To investigate the effect of Yishen Zhuyu method in the treatment of polycystic ovarian syndrome(PCOS)induced infertility in intermingled phlegm and blood stasis type,as well as its influence on glycolipid metabolism and serum C1q and tumoRnecrosis factor-related protein 9(CTRP9)levels in patients.Methods A total of 94 patients with PCOS induced infertility in intermingled phlegm and blood stasis type were selected,and they were randomly assigned to control group oRTraditional Chinese Medicine group,with 47 cases in each group.The control group treated with Western Medicine alone,based on which the Traditional Chinese Medicine group was orally administrated Yishen Zhuyu self-made prescription.The pre-and post-treatment body mass index,glucose metabolic indices(fasting blood glucose[FBG],fasting insulin[Fins],homeostasis model assessment of insulin resistance[HOMA-IR]index),lipid metabolic indices(serum total cholesterol,triacylglycerol,HDL,and LDL),reproductive endocrine indices(follicle-stimulating hormone[FSH],luteinizing hormone[LH],and estradiol),and serum CTRP9 level,as well as the ovulation and pregnancy rates afteRtreatment were compared between the two groups.Results AfteRtreatment,both groups exhibited a loweRbody mass index,FBG level,Fins level,HOMA-IRindex,total cholesterol level,triacylglycerol level,LDL level,and LH level as compared with before treatment,whereas higheRlevels of HDL,FSH,estradiol,and serum CTRP9 as compared with before treatment,and the Traditional Chinese Medicine group yielded a superioRbody mass index,FBG level,Fins level,HOMA-IRindex,and superioRlevels of triacylglycerol,LDL,HDL,LH,FSH,and serum CTRP9 compared to the control group(all P<0.05).The total pregnancy rate and total ovulation rate in the Traditional Chinese Medicine group were higheRthan those in the control group(all P<0.05).Conclusion Based on the routine Western Medicine therapy,the application of Yishen Zhuyu method can preferably elevate the ovulation rate and pregnancy rate to patients with PCOS induced infertility in intermingled phlegm and blood stasis type,and ameliorate the levels of glycolipid metabolism and serum CTRP9.
作者
弓丽华
苏靖
GONG Li-hua;SU Jing(Department of Traditional Chinese Medicine,Panzhihua Central Hospital,Panzhihua 617000,Sichuan,China;Department of Traditional Chinese Medicine,Chengdu Xindu Maternal&Child Health Care Hospital,Chengdu 610017,Sichuan,China)
出处
《广西医学》
CAS
2022年第21期2498-2503,共6页
Guangxi Medical Journal
关键词
多囊卵巢综合征
痰瘀互结型
益肾逐瘀法
糖代谢
脂代谢
排卵率
妊娠率
人C1q肿瘤坏死因子相关蛋白9
Polycystic ovarian syndrome
Intermingled phlegm and blood stasis type
Yishen Zhuyu method
Glucose metabolism
Lipid metabolism
Ovulation rate
Pregnancy rate
Human C1q and tumoRnecrosis factor-related protein 9
