摘要
丝裂原活化蛋白激酶(MAPK)信号通路广泛存在于真核细胞并且高度保守,是生物体内非常重要的信号转导系统之一。胞外刺激信号通过细胞膜上的特异性受体传递给胞内MAPK信号通路,该信号通路通过磷酸化下游转录因子、调节各种酶类来调控转录水平及生化反应等,进而使细胞适应外界环境变化。Hog1 MAPK信号通路能够被胞外高渗透压胁迫等刺激激活,对细胞在高渗环境下的存活至关重要。近年来,越来越多的研究发现虽然该信号通路在真核生物中高度保守,但不同物种中的组成仍有差异,且该信号通路的功能也相对多元化。本文综述了Hog1 MAPK信号通路的组成、功能及其与其他信号通路之间的cross-talk,旨在为今后深入研究该信号通路的作用机制及其与其他信号通路间的cross-talk提供参考。
Mitogen-activated protein kinases(MAPK)pathways are common and well conserved in eukaryotic cells,and they are one of the very important signal transduction systems in living organisms.The extracellular stimulatory signal is transmitted to the intracellular MAPK signaling pathway through specific receptors on the cell membrane,this signaling pathway regulates cellular transcription levels and biochemical reactions by phosphorylating downstream transcription factors and regulating various enzymes,thereby enabling cells to adapt to changes in the external environment.The Hog1 MAPK signaling pathway was activated by stimuli such as extracellular hyperosmotic stress,and was essential for cell survival in a hyperosmotic environment.In recent years,an increasing number of studies have found that although this signaling pathway was highly conserved in eukaryotes,its composition varied from species to species.And the function of this signaling pathway was relatively diversified.This article reviews the composition and function of Hog1 MAPK signaling pathway and the cross-talk between this pathway and other pathways,aiming to provide a reference for further research on the mechanism of Hog1 MAPK signaling pathway and its cross-talk with other signaling pathways.
作者
许机分
陈泓妃
王娜
刘晶
XU Ji-fen;CHEN Hong-fei;WANG Na;LIU Jing(Yunnan Key Laboratory of Potato Biology,Yunnan Normal University,Kunming 650500;Key Laboratory of Potato Biology in Universities of Yunnan Province,Yunnan Normal University,Kunming 650500)
出处
《生物技术通报》
CAS
CSCD
北大核心
2022年第11期32-40,共9页
Biotechnology Bulletin
基金
国家自然科学基金项目(32101665)
云南省基础研究计划项目(202001AU070091)。
