摘要
目的:探讨动态心电图检查联合血清S100钙结合蛋白A4(S100A4)、S100钙结合蛋白P(S100P)对急性心肌梗死诊断和预后评估的价值。方法:选取2019年2月—2020年12月河南大学第一附属医院收治的126例怀疑是急性心机梗死患者作为研究对象,根据冠状动脉造影作为金标准,采用动态心电图检查、检测血清S100A4、S100P水平急性心肌梗死,并进行预后评估。结果:动态心电图灵敏度0.762、特异度0.856、约登指数0.618阳性预测值84.21%、阴性预测值78.26%。血清S100A4灵敏度0.873、特异度0.841、约登指数0.714、阳性预测值84.62%、阴性预测值86.89%。血清S100P灵敏度0.841、特异度0.810、约登指数0.651、阳性预测值80.30%、阴性预测值83.33%。联合检测灵敏度0.937、特异度0.921、约登指数0.858、阳性预测值94.62%、阴性预测值93.44%,明显高于单纯的动态心电图检查、血清S100A4、S100P检测。结论:动态心电图检查、血清S100A4及S100P水平对于急性心肌梗死诊断与预后密切相关,且动态心电图检查联合血清S100A4、S100P对急性心肌梗死诊断和预后评估的价值明显高于单纯动态心电图检查和血清S100A4、S100P检查。
Objective:To investigate the value of the combination of serum S100 calcium-binding protein A4(S100A4)and S100 calcium-binding protein P(S100P)in the diagnosis and prognostic evaluation of acute myocardial infarction by ambulatory electrocardiography.Methods:One hundred and twenty-six patients admitted to the hospital from February 2019 to December2020 with suspected acute heart machine infarction were selected as the study objects.According to coronary angiography as the gold standard,serum S100A4 and S100P levels of acute myocardial infarction were detected using ambulatory electrocardiography,and prognostic evaluation was performed.Results:The sensitivity of the dynamic ECG was 0.762,the specificity was 0.856,and the Jorden index was 0.618,with a positive predictive value of 84.21%and a negative predictive value of 78.26%.The sensitivity of serum S100A4 was 0.873,the specificity was 0.841,and the Jorden index was 0.714,with a positive predictive value of 84.62%and a negative predictive value of 86.89%.The sensitivity of serum S100P was 0.841,the specificity was 0.810,the Jorden index was 0.651,the positive predictive value was 80.30%,and the negative was 83.33%of the predictive value.The combined test had a sensitivity of 0.937,specificity of 0.921,Jorden index of 0.858,positive predictive value of 94.62%and negative predictive value of 93.44%,which were significantly higher than those of dynamic ECG examination alone,serum S100A4 and S100P tests.Conclusion:Ambulatory ECG examination,serum S100A4 and S100P levels were closely related to the diagnosis and prognosis of acute myocardial infarction,and the value of ambulatory ECG examination combined with serum S100A4 and S100P for the diagnosis and prognosis assessment of acute myocardial infarction was significantly higher than that of ambulatory ECG examination and serum S100A4 and S100P examination alone.
作者
范桃红
郑雪梅
董凤娟
安元元
FAN Tao-hong;ZHENG Xue-mei;DONG Feng-juan(Department of Cardio-Brain Function,The First Affiliated Hospital of Henan University,kaifeng,Henan,475000,China)
出处
《黑龙江医学》
2022年第24期2962-2964,共3页
Heilongjiang Medical Journal
基金
开封市科技发展计划项目(1903048)。
关键词
动态心电图
急性心肌梗死
动态心电图检查
Ambulatory electrocardiogram
Acute myocardial infarction
Ambulatory electrocardiography
