摘要
目的:探讨种植牙早期牙周炎性细胞因子的变化及其对牙周健康的影响。方法:选择50例行种植义齿修复的患者为观察组,同期50名牙齿健康志愿者为对照组。比较两组对象牙周龈沟液中炎性因子水平、牙周健康状况及种植体周围病发生状况,多因素Logistics回归分析发生种植体周围病的相关因素。结果:第1天,两组对象牙周龈沟液中C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、IL-6、IL-8、前列腺素E2(PGE2)水平比较,差异无统计学意义(P>0.05);第7天,两组对象各炎性指标均高于第1天,且观察组高于对照组(P<0.05);观察组各炎性指标水平在第3、5及7天均高于对照组(P<0.05),且随时间发展而有上升趋势(P<0.05)。第1天,观察组与对照组牙龈指数(GI)、龈沟探诊深度(SPD)、龈沟出血指数(SBI)及菌斑指数(PLI)水平比较,差异无统计学意义(P>0.05);第7天,观察组牙周健康各指标均高于第1天(P<0.05),且高于对照组(P<0.05);对照组牙周健康各指标随时间发展无统计学差异(P>0.05),观察组牙周健康各指标随时间发展呈上升趋势(P<0.05);患者种植体周围病发生率为24.00%;单因素分析显示,两组对象在是否吸烟、CRP、TNF-α、IL-1β、IL-6、IL-8、PGE2、SPD及PLI方面所占比例比较,差异有统计学意义(P<0.05);回归分析显示,是否吸烟、CRP、TNF-α及PLI水平为影响患者发生种植体周围病的相关因素。结论:种植义齿后,口腔内炎性介质上升,且口腔健康状况呈下降趋势,吸烟、CRP、TNF-α及PLI水平高均为影响患者发生种植体周围病的相关因素,故应督促患者戒烟并采取针对措施降低患者炎症反应程度,改善患者预后。
Objective:To investigate the changes of periodontal inflammatory cytokines and their effects on periodontal health in the early stage of dental implants.Methods:50 patients who underwent implant denture repair were selected as the included subjects and set as the observation group,and 50 healthy people screened during the same period were selected as the control group.The levels of inflammatory factors in periodontal gingival crevicular fluid,periodontal health status and the incidence of peri-implant disease were compared between the two groups,and the related factors of peri-implant disease were analyzed by Logistic multivariate analysis.Results:On the first day,the levels of C-reactive protein(CRP),tumor necrosis factorα(TNF-α),interleukin-1β(IL-1β),IL-6,IL-8 and prostaglandin E2(PGE2)had no significant difference(P>0.05).On the 7th day,the inflammatory indexes of the observation group were higher than those of the control group on the 1st day,and the observation group was higher than the control group(P<0.05),the levels of each inflammatory index in the observation group were higher than those in the control group on the 3rd,5th,and 7th days,and all had an upward trend with time(P<0.05).On the first day,there was no significant difference between the observation group and the control group in the levels of gingival index(GI),sulcus probing depth(SPD),sulcus bleeding index(SBI)and plaque index(PLI)(P>0.05).On the 7th day,the periodontal health indicators in the observation group were higher than the level on the first day,and higher than that in the control group(P<0.05),there was no significant difference in the development of each index of periodontal health in the control group with time(P>0.05),while the development of each index of periodontal health in the observation group showed an upward trend with time(P<0.05).The incidence of peri-implant disease in patients was 24.00%.Univariate analysis showed that there were differences in the proportions of smoking,CRP,TNF-α,IL-1β,IL-6,IL-8,PGE2,SPD and PLI between the observation group and the control group(P<0.05).The Logistic analysis showed that smoking,CRP,TNF-αand PLI levels were the relevant factors affecting the occurrence of peri-implant disease in patients.Conclusion:After denture implantation,the inflammatory mediators in the oral cavity will increase,and the oral health status will show a downward trend.At the same time,smoking,high levels of CRP,TNF-αand PLI are all related factors that affect the occurrence of peri-implant disease in patients,so patients should be urged to quit smoking and take specific measures to reduce the degree of inflammatory response in patients,so as to improve the prognosis of patients.
作者
李小红
郝志军
许应宏
洪荣
李苑荟
LI Xiao-hong;HAO Zhi-jun;XU Ying-hong;HONG Rong;LI Yuan-hui(Department of Stomatology,the Third People's Hospital of Haikou City,Haikou 571100,Hainan,China)
出处
《川北医学院学报》
CAS
2022年第12期1558-1562,共5页
Journal of North Sichuan Medical College
基金
海南省卫生健康行业科研项目(20A200250)。
关键词
种植牙
炎性细胞因子
牙周健康
种植体周围病
Dental implant
Inflammatory cytokines
Periodontal health
Peri-implant disease
