摘要
目的:观察小儿急性支气管炎(AB)经银马解毒颗粒联合头孢曲松钠治疗的临床效果。方法:采用前瞻性随机对照方法,将2020年3月-2022年3月赣州市妇幼保健院收治的81例AB患儿,按照随机数字表法分为观察组(n=41)与对照组(n=40)。对照组使用头孢曲松钠治疗,观察组使用银马解毒颗粒联合头孢曲松钠治疗。比较两组患儿治疗5 d临床效果、治疗期间不良反应;比较两组治疗前后中医症候积分;比较两组患儿治疗前后肺功能指标[潮气量(VT)、达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)]及炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]水平。结果:治疗5 d,观察组患儿总有效率为97.50%,显著高于对照组的80.00%(P<0.05);与治疗前相比,两组患儿治疗5 d主症、次症中医症候积分及血清hs-CRP、IL-1β、TNF-α水平均明显降低,且观察组均低于对照组(P<0.05);与治疗前相比,两组治疗5 d时VT、TPTEF/TE、VPEF/VE均升高,且观察组均更高(P<0.05);观察组不良反应发生率为12.50%,与对照组的5.00%相比,差异无统计学意义(P>0.05)。结论:银马解毒颗粒联合头孢曲松钠治疗小儿AB的效果显著,可有效缓解患儿临床症状,减轻炎症反应,未增加不良反应。
Objective: To observe the clinical effect of Yinma Jiedu Granules combined with Ceftriaxone Sodium in the treatment of acute bronchitis(AB) in children. Method: Prospective randomized control method was used to treat children with AB in Ganzhou Women and Children’s Health Care Hospital from March 2020 to March 2022, according to random number table method, they were divided into observation group(n=41) and control group(n=40). The control group was treated with Ceftriaxone Sodium, while the observation group was treated with Yinma Jiedu Granules combined with Ceftriaxone Sodium. The clinical effect and adverse reactions during 5 days of treatment were compared between the two groups. TCM syndrome scores before and after treatment were compared between the two groups. The levels of pulmonary function indexes [tidal volume(VT), TPTEF/TE, VPEF/VE] and inflammatory factors [hypersensitive C reactive protein(hs-CRP), interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α)] before and after treatment were compared between the two groups. Result: After 5 days of treatment, the total effective rate of observation group was 97.50%, which was significantly higher than 80.00% of control group(P<0.05). Compared with before treatment, TCM syndrome scores of main and secondary symptoms and serum hs-CRP, IL-1β and TNF-α levels were significantly decreased in the two groups after 5 days of treatment,and the observation group were lower than those of the control group(P<0.05). Compared with before treatment, VT,TPTEF/TE and VPEF/VE in the two groups were increased after 5 days of treatment, and those in the observation group were higher(P<0.05). The incidence of adverse reactions in the observation group was 12.50%, which was not statistically significant compared with 5.00% in the control group(P>0.05). Conclusion: Yinma Jiedu Granules combined with Ceftriaxone Sodium has a significant effect in the treatment of AB in children, which can effectively relieve the clinical symptoms of children, reduce inflammation, and do not increase adverse reactions.
作者
文伟
刘燕青
李政
WEN Wei;LIU Yanqing;LI Zheng(Ganzhou Women and Children’s Health Care Hospital,Jiangxi Province,Ganzhou 341000,China;不详)
出处
《中国医学创新》
CAS
2022年第35期91-95,共5页
Medical Innovation of China
基金
江西省卫生计生委科技计划项目(20204658)。
