摘要
目的 探讨疏血通对急性脑梗死患者的认知行为学及神经影像学的影响。方法 选取诊治的急性脑梗死患者80例,随机分为对照组与观察组,每组40例,给予急性脑梗死常规规范化治疗,观察组同时给予疏血通注射液静脉滴注,治疗疗程均为14 d,观察治疗前后观中医证候积分变化,采用简易精神状态量表(mini-mental state examination, MMSE)及蒙特利尔认知评估量表(montreal cognitive assessment, MOCA)评估患者认知行为,采用美国国立卫生研究院脑卒中量表(NIH stroke scale, NIHSS)评估患者神经功能,采用CT及超导磁共振对梗死灶体积、相对表观扩散系数值(apparent diffusion coefficient, rADC)及基底节区脑血流量(cerebral blood flow, CBF)、脑血流平均通过时间(meantransit time, MTT)、脑血流容积(cerebral blood volume, CBV)进行测定。结果 两组患者治疗前中医证候积分的比较差异无统计学意义(P>0.05),治疗后积分下降(P<0.05),且观察组下降幅度大于对照组(P<0.05);两组患者治疗前MMSE、MOCA、NIHSS评分比较差异无统计学意义(P>0.05),治疗后MMSE、MOCA评分升高(P<0.05),且观察组升高幅度大于对照组(P<0.05),NIHSS评分下降(P<0.05),且观察组下降幅度大于对照组(P<0.05);两组患者治疗前梗死灶体积、rADC、CBF、MTT、CBV比较差异无统计学意义(P>0.05),治疗后梗死灶体积、MTT下降(P<0.05),且观察组下降幅度大于对照组(P<0.05),rADC、CBF、CBV升高(P<0.05),且观察组升高幅度大于对照组(P<0.05)。结论 疏血通应用于急性脑梗死患者的治疗有助于中医证候、认知功能的改善,促进神经功能缺损的恢复,神经影像学下有脑血流灌注的改善及梗死灶体积的减少的表现。
Objective To discuss the effects of Shuxuetong(疏血通)on cognitive behavior and neuroimaging in patients with acute cerebral infarction.Methods We collected 80 patients with acute cerebral infarction were randomly divided into control group and observation group with 40 cases in each group.The patients received routine standard treatment.Besides,the observation group was also given Shuxuetong Injection by intravenous drip and the treatment lasted for 14 days.The changes of TCM syndrome score before and after treatment were observed.The patients’cognitive behavior was assessed by the Simplified Mental State Scale(MMSE)and Montreal Cognitive Assessment Scale(MOCA).The neurological function was assessed by using the National Institutes of Health Stroke Scale(NIHSS).The infarct volume,relative apparent diffusion coefficient(rADC),basal ganglia cerebral blood flow(CBF),mean time of cerebral blood flow(MTT)and cerebral blood flow volume(CBV)were measured by CT and superconducting magnetic resonance.Results There was no significant difference in TCM symptom scores between the two groups before treatment(P>0.05)and the score decreased after treatment(P<0.05).The decrease of the observation group was greater than that of the control group(P<0.05).There was no significant difference in MMSE,MOCA or NIHSS scores between the two groups before treatment(P>0.05).After treatment,MMSE and MOCA scores increased(P<0.05),and the increase of the observation group was greater than that of the control group(P<0.05).NIHSS score decreased(P<0.05),and the decrease of the observation group was greater than that of the control group(P<0.05).There were no significant differences in infarct volume,rADC,CBF,MTT or CBV between the two groups before treatment(P>0.05).After treatment,the infarct volume and MTT decreased(P<0.05),and the decrease of the observation group was greater than that of the control group(P<0.05).The levels of rADC,CBF and CBV scores increased after treatment(P<0.05),and the increase of the observation group was greater than that of the control group(P<0.05).Conclusion The application of Shuxuetong in the treatment of patients with acute cerebral infarction is helpful to the improvement of TCM symptoms and cognitive function,and it can promote the recovery of nerve function defect,improve cerebral blood perfusion and reduce infarct volume under neuroimaging.
作者
樊冰
王阳
宁绍爽
FAN Bing;WANG Yang;NING Shaoshuang(Department of Medical Imaging,Department of Medical Technology,Nanyang Medical College,Nanyang 453003,Henan,China;The First Affiliated Hospital of Nanyang Medical College,Nanyang 453003,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第11期100-103,共4页
Chinese Archives of Traditional Chinese Medicine
基金
中华医学会临床医学科研专项(192707835965)
河南省高等学校青年骨干教师培养计划(2020GGJS179)。
关键词
疏血通
急性脑梗死
认知行为
神经影像学
Shuxuetong(疏血通)
acute cerebral infarction
cognitive behavior
neuroimaging
