摘要
目的 观察痛痹补肾方治疗骨质疏松症肾虚血瘀证的临床疗效。方法 选择湖北省中医院内分泌科门诊骨质疏松症肾虚血瘀证患者80例,采用随机数字表法分为2组。对照组40例采用常规抗骨质疏松治疗,治疗组40例在对照组治疗基础上加痛痹补肾方治疗,2组均治疗3个月。比较2组治疗前后骨代谢指标、中医证候积分、骨密度、疼痛症状,比较2组临床疗效。结果 治疗后,2组血清β-胶原特殊序列(β-CTX)水平较本组治疗前降低(P<0.05),血清Ⅰ型胶原氨基末端肽(PⅠNP)、骨钙素(BGP)水平较本组治疗前升高(P<0.05),且治疗组治疗后β-CTX水平低于对照组(P<0.05),PⅠNP、BGP水平高于对照组(P<0.05)。治疗后,2组各项中医证候评分及总分均较本组治疗前降低(P<0.05),且治疗组治疗后显著低于对照组(P<0.05)。治疗后,2组腰椎、股骨颈骨密度均无明显改善(P>0.05),组间比较差异也无统计学意义(P>0.05)。治疗后,2组疼痛视觉模拟评分(VAS)均较本组治疗前降低(P<0.05),且治疗组治疗后低于对照组(P<0.05)。治疗组总有效率90.00%(36/40),对照组为70.00%(28/40),治疗组疗效优于对照组(P<0.05)。结论 痛痹补肾方能调节骨质疏松症肾虚血瘀证患者骨代谢,改善肾虚血瘀证中医证候,降低疼痛,提高临床疗效。
Objective To observe the clinical efficacy of Tongbi Bushen Formula for osteoporosis(OP) of kidney deficiency blood stasis syndrome.Methods Totally 80 OP patients(kidney deficiency blood stasis syndrome) admitted to the Department of Endocrinology, Hubei Provincial Hospital of TCM. They were randomized 1∶1 to receiveanti-osteoporosis treatment(the control group) or Tongbi Bushen Formula+ anti-osteoporosis treatment(the treatment group) for 3 months. The aim was to compare bone metabolism index, traditional Chinese medicine(TCM) symptom scores, bone mineral density(BMD), pain symptoms. The curative effect was assessed. Results After treatment, beta-collagen-specific sequences(β-CTX) in groups was decreased(P<0.05), while serum amino-terminal propeptide of type 1 collagen(PⅠNP) and bone Gla protein(BGP) were increased(P<0.05).Significantly lower β-CTX level, and significantlyhigher PⅠNP and BGP levels were detected in the treatment grouprelative tothe control group(all P<0.05);TCM symptom scores in groups were decreased(P<0.05), which were decreased in the treatment group compared with control group(P<0.05). No differencewas statistically significant in BMD of lumbar vertebra and femur neck between groups(P>0.05). The visual analogue scale(VAS) in groups was decreased(P<0.05), which was more pronounced in the treatment group compared with the control group(P<0.05). The overall effective rate in the treatment group was better than that in the control group(90.00% [36/40] vs 70.00% [28/40], [P<0.05], respectively).Conclusion For OP patients(kidney deficiency blood stasis syndrome), Tongbi Bushen Recipe can regulate bone metabolism, improve TCM syndromes, reduce pain symptoms, with good clinical efficacy.
作者
王平
左新河
喻秀兰
王芳
WANG Ping;ZUO Xinhe;YU Xiulan;WANG Fang(Department of Endocrinology,Hubei Provincial Hospital of TCM,Wuhan,Hubei 430074)
出处
《河北中医》
2022年第11期1817-1820,共4页
Hebei Journal of Traditional Chinese Medicine
关键词
骨质疏松
肾虚血瘀
中医治疗
骨代谢
骨密度
疼痛
Osteoporosis
Blood stasis upon kidney-deficiency
Traditional Chinese medicine treatment
Bone metabolism
Bone mineral density
Pain
