摘要
目的 探究血清癌胚抗原(CEA)、糖链抗原242(CA242)及计算机断层扫描(PET/CT)联合检测对胰腺癌的诊断价值。方法 回顾性选取2016年6月至2020年10月拟诊断为胰腺癌的患者106例为研究对象。所有患者均术前进行血清CEA、CA242检测及PET/CT显像检查,分析血清CEA、CA242与PET/CT显像联合检测对胰腺癌患者的临床诊断价值。结果 106例拟诊断为胰腺癌的患者行手术病理显示胰腺癌患者88例,胰腺良性疾病者18例。胰腺癌组血清CEA、CA242水平分别为(^(18).58±5.69)ng/mL、(41.55±14.42)U/mL,均高于胰腺良性组的(10.92±2.24)ng/mL、(^(18).68±6.25)U/mL (P<0.05)。PET/CT影像显示胰腺癌患者病灶可见^(18)F-FDG代谢增加,且病变局部放射性浓集明显增高,胰腺良性疾病中显示病变局部放射性浓集不增高或轻微增高。PET/CT影像检查诊断胰腺癌的敏感度、特异度、准确度分别为88.6%、77.8%、86.79%,血清CEA诊断胰腺癌的敏感度、特异度、准确度为84.1%、66.7%、81.13%,血清CA242诊断胰腺癌的敏感度、特异度、准确度为85.2%、72.2%、83.02%,联合检测诊断胰腺癌的敏感度、特异度、准确度为95.5%、94.4%、95.28%,均高于单项检测。结论 血清CEA、CA242和PET/CT显像联合检测对胰腺癌的诊断价值高。
Objective To investigate the diagnostic value of serum carcinoembryonic antigen(CEA), sugar chain antigen 242(CA242) and computed tomography(PET/CT) in pancreatic cancer. Methods From June 2016 to October 2020,106 patients with pancreatic cancer were selected as the subjects. Serum CEA, CA242 and PET/CT imaging were performed in all patients before operation to analyze the clinical diagnostic value of serum CEA、CA242 level and PET/CT imaging in pancreatic cancer patients. Results Surgical pathology of 106 patients with pancreatic cancer, There were 18 cases of benign pancreatic diseases. Serum CEA、CA242 levels in pancreatic cancer group were(18.58±5.69)ng/mL、(41.55±14.42)U/mL, respectively were higher than those in the benign group of pancreas(10.92±2.24)ng/mL,(^(18).68±6.25)U/mL(P<0.05). PET/CT images showed that ^(18)F-FDG of metabolism increased in pancreatic cancer patients, and the local radioactivity concentration was significantly increased, and the local radioactivity concentration was not increased or slightly increased in benign pancreatic diseases. PET/CT sensitivity, specificity and accuracy were 88.6%, 77.8% and 86.79% respectively, Serum CEA sensitivity, specificity and accuracy were 84.1%, 66.7%, 81.13%, Serum CA242 sensitivity, specificity and accuracy were 85.2%, 72.2%, 83.02%, The sensitivity, specificity and accuracy of the combined detection were 95.5%, 94.4%, 95.28%, All were higher than single test. Conclusion The combined detection of serum CEA, CA242 and PET/CT imaging has high diagnostic value for pancreatic cancer.
作者
李林
毛朝明
司马玉洁
牟笑
周建明
LI Lin;MAO Zhao-ming;SIMA Yu-jie;MOU Xiao;ZHOU Jian-ming(Department of Nuclear Medicine,Affiliated Hospital of Jiangsu University,Zhenjiang 212000,Jiangsu Province,China)
出处
《中国CT和MRI杂志》
2023年第1期115-116,185,共3页
Chinese Journal of CT and MRI
关键词
胰腺癌
癌胚抗原
糖链抗原242
计算机断层扫描
诊断价值
Pancreatic Cancer
Carcinoembryonic Antigen
Sugar Chain Antigen 242
Computed Tomography
Diagnostic Value
