摘要
目的 研究唑来膦酸、化疗联合多维度协同管理治疗非小细胞肺癌骨转移疗效及疼痛程度和生活质量影响。方法 选取2019年6月-2022年7月在我院诊治的78例非小细胞肺癌骨转移患者为研究对象,采用随机数字表法分为对照组和观察组,各组39例。对照组采用化疗联合多维度协同管理,观察组在对照组基础上给予唑来膦酸治疗,比较两组临床疗效、疼痛程度、心理状况、生活质量及不良反应发生情况。结果 观察组总有效率为76.92%,高于对照组的56.41%(P<0.05);观察组0级、Ⅰ级疼痛程度占比均高于对照组,Ⅱ级、Ⅲ级均低于对照组(P<0.05);两组焦虑、抑郁评分均低于治疗前,生活质量量表各维度评分均高于治疗前,且观察组焦虑、抑郁评分低于对照组,生活质量量表各维度评分高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 唑来膦酸、化疗联合多维度协同管理治疗非小细胞肺癌骨转移效果确切,可一定程度提高临床疗效,减轻患者疼痛程度,提高其生活质量水平,改善其心理状况,且不良反应少,具有较理想的有效性、安全性。
Objective To study the efficacy of zoledronic acid and chemotherapy combined with multi-dimensional collaborative management in the treatment of bone metastasis of non-small cell lung cancer and its influence on pain degree and quality of life. Methods A total of 78 patients with bone metastasis of non-small cell lung cancer diagnosed and treated in our hospital from June 2019 to July 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 39 cases in each group. The control group was treated with chemotherapy combined with multidimensional collaborative management, and the observation group was treated with zoledronic acid on the basis of the control group. The clinical efficacy, pain degree, psychological status, quality of life and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 76.92%, which was higher than 56.41% of the control group( P<0.05).The proportion of grade 0 and grade Ⅰ pain in the observation group was higher than that in the control group, and grade Ⅱ and grade Ⅲ were lower than those in the control group(P <0.05). The scores of anxiety and depression in the two groups were lower than those before treatment, and the scores of each dimension of the quality of life scale were higher than those before treatment, and the scores of anxiety and depression in the observation group were lower than those in the control group, and the scores of each dimension of the quality of life scale were higher than those in the control group(P <0.05).There was no significant difference in the incidence of adverse reactions between the two groups( P >0.05).Conclusion Zoledronic acid, chemotherapy combined with multi-dimensional collaborative management is effective in the treatment of bone metastasis of non-small cell lung cancer, which can improve the clinical efficacy to a certain extent, reduce the pain of patients, improve their quality of life, improve their psychological status, and have fewer adverse reactions. It has ideal effectiveness and safety.
作者
李垄英
王启平
黄慧
LI Long-ying;WANG Qi-ping;HUANG Hui(Department of Oncology,Dayu County People's Hospital,Dayu 341500,Jiangxi,China)
出处
《医学信息》
2022年第21期98-100,共3页
Journal of Medical Information
基金
赣州市指导性科技计划(编号:GZ2021ZSF493)。
关键词
唑来膦酸
多维度协同管理
非小细胞肺癌
骨转移
疼痛程度
生活质量
Zoledronic acid
Multi-dimensional collaborative management
Non-small cell lung carcinoma
Bone metastasis
Pain degree
Quality of life
