摘要
颌骨缺损修复始终是临床上面临的重大难题,这也推动了对骨缺损修复材料的深入研究。目前对于能更好实现临床应用的人工骨缺损修复材料,除了追求优异的力学性能、生物相容性等,材料的生物学活性尤其是促成骨性能也逐渐受到重视,很多研究在材料表面改性、纳米形貌修饰、添加生物活性离子或涂层等方面不断创新。本文就近年通过利用不同金属元素的作用来增强骨修复材料的成骨性能的研究进展做一综述,重点阐述现有研究中哪些金属离子可以发挥促成骨作用,对细胞产生何种影响以及相关的分子机制,除此之外,本文还总结了一些金属元素促进成骨常见的分子信号通路和共性机制,希望可以为后续相关研究提供思路,为骨修复材料的改性创新提供参考。
The repair of maxillofacial bone defects is always a major clinical problem,which promotes the in-depth study of artificial bone repair materials.Numerous bone repair materialsare now used extensively in clinical practice.Although they show good performance in some aspects,they still have shortcomings in promoting biological activity of osteogenesis.In recent years,in order to improve the mechanical or biological properties of bone repair materials,many researches have been innovating in the aspects of material surface modification,nano-morphology change,addition of bioactive ions or coatings,hoping to improve the performance of materials promoting bone regeneration.This paper reviews the use of various metallic elements to enhance the effect of bone regeneration,focusing on the effects of metal ions on osteogenesis and the related molecular mechanisms.In addition,this paper also summarizes some common signaling pathways and mechanisms of metal elements promoting osteogenesis,hoping to provide ideas and reference for modification and innovation of bone repair materials.
作者
刘子杨
李雅欣
刘加强
LIU Zi-yang;LI Ya-xin;LIU Jia-qiang(Department of Oral&Cranio-Maxillofacial Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China)
出处
《口腔颌面修复学杂志》
2023年第1期52-59,共8页
Chinese Journal of Prosthodontics
基金
国家自然科学基金面上项目(项目编号:82071081)。
关键词
金属
离子
生物材料
骨髓间充质干细胞
成骨分化
信号通路
骨生成
metal
ion
biomaterial
bone marrow mesenchymal stem cells
osteogenic differentiation
signaling pathways
osteogensis
