摘要
当今代谢性疾病高发造成了沉重的医疗和社会负担。中医痰湿体质是一种易发多种代谢性疾病的体质类型,通过痰湿体质临床调体可实现对于多种代谢性疾病的异病同治。脾失健运是痰湿体质代谢异常的重要病理基础,揭示脾失健运的内在机制,对于指导中医痰湿体质临床调体以及代谢性疾病的治疗具有重要意义。文章从肠道菌群以及后生元的角度阐释脾失健运的分子机制,有助于对中医经典理论在科研层面进行更深入解读,为探索痰湿体质的微观机制以及进一步指导临床调体提供新的科学依据。
Nowadays,the high incidence of metabolic diseases has caused heavy medical and social burdens.Phlegm-dampness constitution of traditional Chinese medicine(TCM)is a constitution type that has the predisposition to a variety of metabolic diseases.Through the clinical regulation of phlegm-dampness constitution,we can achieve the same treatment for different metabolic diseases.Spleen dysfunction is an important pathological basis of metabolism disorder of phlegm-dampness constitution.Revealing the internal mechanism of spleen dysfunction is of great significance to guide the clinical regulation of phlegm-dampness constitution and the treatment of metabolic diseases.The present work explores the molecular mechanism of spleen dysfunction from intestinal flora and postbiotics,which is helpful for a more in-depth interpretation of the classical theories of traditional Chinese medicine at the scientific research level,and provides a new scientific basis for exploring the micro-mechanism of the phlegm-dampness constitution and further guiding clinical practice.
作者
吴玉琦
王琦
姚海强
万瑾毅
WU Yu-qi;WANG Qi;YAO Hai-qiang;WAN Jin-yi(Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2022年第12期7455-7458,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81973714)
中华中医药学会“青年人才托举工程”(No.CACM-2019-QNRC2-A01)
北京中医药大学“青年科学家培育计划”,中央高校基本科研业务费专项资金资助(No.2020-JYB-XJSJJ-003)
北京中医药大学高层次人才项目(No.2021-XJ-KYQD-004)。
关键词
痰湿体质
脾失健运
肠道菌群
后生元
代谢紊乱
Phlegm-dampness constitution
Spleen dysfunction
Gut microbiota
Postbiotics
Metabolic disorder
